Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GlaxoSmithKline, Cambridge, MA, USA.
Methods Mol Biol. 2022;2541:39-43. doi: 10.1007/978-1-0716-2545-3_6.
Copper-catalyzed azide-alkyne cycloaddition (CuAAC) provides a simple and convenient strategy to synthesize diverse 1,2,3-triazoles for drug discovery. Described herein is a protocol for the CuSO-catalyzed cycloaddition between alkynes and DNA-appended azides.
铜催化的叠氮-炔环加成（CuAAC）为药物发现提供了一种简单方便的合成各种 1,2,3-三唑的策略。本文描述了一种在 CuSO 催化下炔烃与 DNA 连接的叠氮化物之间的环加成反应的方案。
