通过点击反应在 DNA 上形成 1,2,3-三唑。
On-DNA-1,2,3-Triazole Formation via Click Reaction.
机构信息
Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GlaxoSmithKline, Cambridge, MA, USA.
出版信息
Methods Mol Biol. 2022;2541:39-43. doi: 10.1007/978-1-0716-2545-3_6.
PMID:36083541
Abstract
Copper-catalyzed azide-alkyne cycloaddition (CuAAC) provides a simple and convenient strategy to synthesize diverse 1,2,3-triazoles for drug discovery. Described herein is a protocol for the CuSO-catalyzed cycloaddition between alkynes and DNA-appended azides.
摘要
铜催化的叠氮-炔环加成（CuAAC）为药物发现提供了一种简单方便的合成各种 1,2,3-三唑的策略。本文描述了一种在 CuSO 催化下炔烃与 DNA 连接的叠氮化物之间的环加成反应的方案。
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