Unit of Internal Medicine, Campus Bio Medico University and Teaching Hospital, 00128 Rome, Italy.
Unit of Geriatrics, Campus Bio Medico University and Teaching Hospital, 00128 Rome, Italy.
Biosensors (Basel). 2020 Nov 11;10(11):171. doi: 10.3390/bios10110171.
Chronic obstructive pulmonary disease (COPD) is a common progressive disorder of the respiratory system which is currently the third leading cause of death worldwide. Exhaled breath analysis is a non-invasive method to study lung diseases, and electronic noses have been extensively used in breath research. Studies with electronic noses have proved that the pattern of exhaled volatile organic compounds is different in COPD. More recent investigations have reported that electronic noses could potentially distinguish different endotypes (i.e., neutrophilic vs. eosinophilic) and are able to detect microorganisms in the airways responsible for exacerbations. This article will review the published literature on electronic noses and COPD and help in identifying methodological, physiological, and disease-related factors which could affect the results.
慢性阻塞性肺疾病（COPD）是一种常见的呼吸系统进行性疾病，目前是全球第三大致死原因。呼气分析是一种研究肺部疾病的非侵入性方法，电子鼻已广泛应用于呼吸研究中。电子鼻的研究已经证明，COPD 患者呼气中挥发性有机化合物的模式是不同的。最近的研究报告称，电子鼻有可能区分不同的表型（即嗜中性粒细胞与嗜酸性粒细胞），并能够检测到导致加重的气道中的微生物。本文将综述已发表的关于电子鼻和 COPD 的文献，并帮助确定可能影响结果的方法学、生理学和疾病相关因素。
