Hultcrantz M
Department of Otolaryngology, Karolinska Hospital, Stockholm, Sweden.
Arch Otorhinolaryngol. 1987;244(4):229-35. doi: 10.1007/BF00455311.
Pregnant CBA/CBA mice were exposed to 1 and 2 Gy whole-body gamma irradiation on the 13th and 16th gestational days, respectively. The litters were born on the 21st day of gestation and were tested for vestibular function at the age of 1 month. The animals were then sacrificed and their inner ears were analyzed by scanning electron microscopy. No disturbances of vestibular function were noted in the animals studied. However, the cristae ampullares showed severe malformations as regards their gross shape, with irregularities of their outer contours. Type I hair cells seemed to be more severely changed than Type II hair cells, with fusion of sensory hairs, giant hair formation and bulging of the cuticular plate. In certain sites the hair cells were totally missing. These derangements were usually located in the central areas of the cristae ampullares and in the striolar portion of the maculae utriculi. The morphological damage found showed a dose-dependent, time-related pattern.
将怀孕的CBA/CBA小鼠分别在妊娠第13天和第16天接受1 Gy和2 Gy的全身γ射线照射。仔鼠在妊娠第21天出生，并在1月龄时进行前庭功能测试。然后处死动物，通过扫描电子显微镜分析其内耳。在所研究的动物中未发现前庭功能障碍。然而，壶腹嵴的总体形态显示出严重畸形，其外轮廓不规则。I型毛细胞似乎比II型毛细胞变化更严重，表现为感觉毛融合、巨大毛形成和角质板隆起。在某些部位，毛细胞完全缺失。这些紊乱通常位于壶腹嵴的中央区域和椭圆囊斑的纹状部。所发现的形态学损伤呈现出剂量依赖性和时间相关性模式。
