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Vestibular hair cell pathology in the Shaker-2 mouse.

作者信息

Anniko M, Sobin A, Wersäll J

出版信息

Arch Otorhinolaryngol. 1980;226(1-2):45-50. doi: 10.1007/BF00455401.

DOI:10.1007/BF00455401
PMID:6258550
Abstract

The circling-waltzing behaviour of the Shaker-2 mouse is suggested, at least in part, to be of peripheral origin. In this hereditary inner ear disease, degeneration of hair cells type I has been observed showing specific pathologic features: rod-shaped inclusion bodies and sensory hair fusion. Later, the hair cells type I are expelled into the endolymphatic space. A large number of sensory cells type II are morphologically normal. The failure of earlier investigators to demonstrate pathological changes in the sensory epithelia of this animal is likely to be due to the use of light microscopical methods only.

摘要

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本文引用的文献

1
Hereditary lesions of the labyrinth in the mouse.小鼠迷宫的遗传性病变
Br Med Bull. 1956 May;12(2):153-7. doi: 10.1093/oxfordjournals.bmb.a069538.
2
Inherited diseases of the inner ear in man in the light of studies on the mouse.基于对小鼠的研究看人类内耳的遗传性疾病
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Morphologic changes in vestibular hair cells in a strain of the waltzing guinea pig.
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一项对小鼠前庭系统中whirlin亚型的研究表明,DFNB31缺陷患者可能存在前庭功能障碍。
Hum Mol Genet. 2015 Dec 15;24(24):7017-30. doi: 10.1093/hmg/ddv403. Epub 2015 Sep 29.
4
Genetics of peripheral vestibular dysfunction: lessons from mutant mouse strains.外周前庭功能障碍的遗传学:来自突变小鼠品系的经验教训。
J Am Acad Audiol. 2014 Mar;25(3):289-301. doi: 10.3766/jaaa.25.3.8.
5
Age-related changes in cochlear gene expression in normal and shaker 2 mice.正常小鼠和shaker 2小鼠耳蜗基因表达的年龄相关变化。
J Assoc Res Otolaryngol. 2006 Sep;7(3):317-28. doi: 10.1007/s10162-006-0046-7. Epub 2006 Jun 23.
6
A quantitative survey of gravity receptor function in mutant mouse strains.突变小鼠品系重力感受器功能的定量研究。
J Assoc Res Otolaryngol. 2005 Dec;6(4):297-310. doi: 10.1007/s10162-005-0009-4.
7
Deterioration of the elemental composition of endolymph in genetic inner ear disease.遗传性内耳疾病中内淋巴元素组成的恶化。
Arch Otorhinolaryngol. 1980;228(3):171-86. doi: 10.1007/BF00454225.
8
Rods of actin filaments in type I hair cells of the Shaker-2 mouse.震颤2型小鼠I型毛细胞中肌动蛋白丝的杆状结构。
Arch Otorhinolaryngol. 1982;236(1):1-6. doi: 10.1007/BF00464051.
9
A scanning electron microscopic study of vestibular organ malformation following prenatal gamma irradiation.产前γ射线照射后前庭器官畸形的扫描电子显微镜研究
Arch Otorhinolaryngol. 1987;244(4):229-35. doi: 10.1007/BF00455311.
4
Actin filaments in sensory hairs of inner ear receptor cells.内耳感受器细胞感觉毛中的肌动蛋白丝。
J Cell Biol. 1977 Nov;75(2 Pt 1):339-43. doi: 10.1083/jcb.75.2.339.
5
Pathological actin in vestibular hair cells of the waltzing guinea pig.华尔兹豚鼠前庭毛细胞中的病理性肌动蛋白。
Adv Otorhinolaryngol. 1979;25:12-6. doi: 10.1159/000402911.