Oral and Maxillofacial Surgery, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia; Faculty of Medicine, University of Queensland, Herston, Queensland, Australia.
Oral and Maxillofacial Surgery, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2021 Jan;131(1):92-98. doi: 10.1016/j.oooo.2020.09.012. Epub 2020 Oct 5.
Oral squamous cell carcinoma (SCC) has been traditionally described as a highly lethal disease. This study aims to provide updated multi-institutional data on the survival of patients with oral SCC in Australia.
Retrospective survival analysis was performed between 2008 and 2016. All new patients with oral SCC treated with curative intent were recruited from 2 high-volume Australian head and neck oncology centers. Outcomes were measured in overall survival (OS), disease-specific survival (DSS), disease-free survival, and salvage rates for recurrences.
Survival analysis included 771 patients with oral SCC. Five-year OS and DSS were 66.1% and 79.7%, respectively. Stage I and II oral SCC had significantly better survival than higher stages. Five-year OS and DSS for patients with stage I SCC were 79.7% and 93.4%, respectively, and for patients with stage IVB they were 37.9% and 54.3%, respectively. Two hundred forty-nine patients had disease recurrence (32.3%), with 66 patients (26.5% remaining disease free post salvage treatment.
Survival outcomes for oral SCC among Australian patients have improved, possibly due to advances in multidisciplinary care. Early detection of oral SCC leads to highly favorable prognosis; there is therefore an opportunity for routine oral cancer screening to be performed by community health practitioners with the aim of improving survival from oral SCC.
口腔鳞状细胞癌（SCC）传统上被描述为一种高致死性疾病。本研究旨在提供澳大利亚口腔 SCC 患者生存的最新多机构数据。
在 2008 年至 2016 年期间进行了回顾性生存分析。从 2 家澳大利亚头颈肿瘤学中心招募了所有接受根治性治疗的新的口腔 SCC 患者。通过总生存（OS）、疾病特异性生存（DSS）、无病生存和复发挽救率来衡量结果。
生存分析包括 771 例口腔 SCC 患者。5 年 OS 和 DSS 分别为 66.1%和 79.7%。I 期和 II 期口腔 SCC 的生存明显优于更高分期。I 期 SCC 患者的 5 年 OS 和 DSS 分别为 79.7%和 93.4%，IVB 期患者分别为 37.9%和 54.3%。249 例患者发生疾病复发（32.3%），66 例（26.5%）患者在挽救治疗后仍无疾病。
澳大利亚患者的口腔 SCC 生存结果有所改善，这可能是由于多学科治疗的进步。口腔 SCC 的早期发现可带来极好的预后；因此，有机会由社区卫生从业者进行常规口腔癌筛查，以提高口腔 SCC 的生存率。
