Matthews D M
Beitr Infusionther Klin Ernahr. 1987;17:6-53.
This review touches on the development of the concept of transmembrane transport of peptides, which originated more than 100 years ago, and discusses present knowledge of the phenomenon, with special reference to intestinal absorption of peptides. It deals with (1) Peptide transport in animal small intestine and its main features--active transport of di- and tripeptides into the absorptive cells, the question of sodium or proton dependence of peptide transport, the independence of peptide and amino acid transport, competition for transport between peptides, the number of transport systems involved, the influence of molecular structure on peptide transport, transport kinetics and relative rates of absorption of peptides and amino acids, nutritional and therapeutic aspects of peptide transport, mechanisms of absorption of small peptides of dietary origin and mechanisms of absorption of biologically active peptides (2) Peptide transport in other animal cells and tissues (3) Peptide transport in microorganisms (4) Peptide transport in higher plants and (5) Physiological advantages of peptide transport. The concluding remarks stress that though most of the salient features of peptide absorption may have been established by 1975, more investigators might usefully be engaged in studying the many remaining questions concerning peptide transport in the animal body, and point out the unfortunate effects of too narrow an approach to problems in the field.
本综述涉及肽跨膜转运概念的发展，该概念起源于100多年前，并讨论了这一现象的现有知识，特别提及肽的肠道吸收。它涉及：（1）动物小肠中的肽转运及其主要特征——二肽和三肽向吸收细胞的主动转运、肽转运对钠或质子的依赖性问题、肽转运与氨基酸转运的独立性、肽之间的转运竞争、涉及的转运系统数量、分子结构对肽转运的影响、肽转运动力学以及肽和氨基酸的相对吸收速率、肽转运的营养和治疗方面、膳食来源的小肽的吸收机制以及生物活性肽的吸收机制；（2）其他动物细胞和组织中的肽转运；（3）微生物中的肽转运；（4）高等植物中的肽转运；以及（5）肽转运的生理优势。结论强调，尽管到1975年肽吸收的大多数显著特征可能已被确立，但更多的研究人员可能会有益地致力于研究动物体内肽转运的许多遗留问题，并指出该领域对问题研究方法过于狭隘所带来的不良影响。
