Heydenreich G, Pindborg T, Schmidt H
Acta Med Scand. 1977;202(1-2):61-4. doi: 10.1111/j.0954-6820.1977.tb16784.x.
Twelve of 56 patients with chronic renal failure, all treated with frusemide (Lasix) in daily doses of 0.5-2 g, developed bullae in areas exposed to light. In most cases the bullae developed during summer months and disappeared later in the year whether the frusemide treatment was continued or not. In two patients the eruption reappeared when treatment was resumed. Disturbance of the porphyrin metabolism was not found, neither could a change in the frusemide metabolism be demonstrated. Tissue typing and blood groups showed no difference from the average population. It is concluded that the condition presumably is a photo reaction due to the frusemide treatment but it cannot be said whether it is allergic or toxic.
56例慢性肾衰竭患者均接受速尿（呋塞米）治疗，日剂量为0.5 - 2克，其中12例患者在暴露于光线的部位出现大疱。多数情况下，大疱在夏季出现，无论速尿治疗是否继续，在当年晚些时候都会消失。有2例患者在恢复治疗时皮疹复发。未发现卟啉代谢紊乱，也未证实速尿代谢有变化。组织分型和血型与普通人群无差异。结论是，这种情况可能是速尿治疗引起的光反应，但无法确定是过敏性还是中毒性的。
