Diagnostic Center for Oral Diseases, School of Dentistry, Universidade Federal de Pelotas, Pelotas, Brazil.
Department of Conservative Dentistry, Oral Pathology area, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
J Oral Pathol Med. 2021 Jan;50(1):103-113. doi: 10.1111/jop.13127. Epub 2020 Dec 7.
Intravascular papillary endothelial hyperplasia is an unusual vascular lesion characterized by the proliferation of endothelial cells. The aim of this study was to determine the frequency and general features of this lesion.
Biopsy records of three oral pathology services were reviewed for intravascular papillary endothelial hyperplasia cases from 1959 to 2020. In addition, a systematic review of case reports and case series was carried out in eight electronic databases.
Of the 65 205 retrieved cases, 20 (0.03%) were diagnosed as intravascular papillary endothelial hyperplasia. Mean patient age was 46.55 years, and females (12 cases/60%) were more affected. The lower lip (9 cases/47.36%) was the most commonly affected site, and the lesions were generally asymptomatic (7 cases/63.63%). Clinically, 90% of the lesions presented (18 cases) as a nodule, with a mean size of 1.13 cm. The clinical diagnostic hypotheses most frequently raised were mucocele (6 cases/37.50%) and hemangioma (5 cases/31.25%). An excisional biopsy was chosen in all cases for treatment. Forty-nine studies of the systematic review were included, yielding 105 cases. The literature showed similarity in all variables.
Despite the uncommon frequency, clinicians and oral pathologists should familiarize themselves with the similarities between intravascular papillary endothelial hyperplasia and some other lesions in terms of clinical and histological features.
血管内乳头状内皮细胞增生是一种不常见的血管病变，其特征为内皮细胞的增生。本研究旨在确定该病变的频率和一般特征。
回顾了三个口腔病理服务机构从 1959 年到 2020 年的血管内乳头状内皮细胞增生病例的活检记录。此外，还在八个电子数据库中进行了病例报告和病例系列的系统回顾。
在 65205 例检索病例中，有 20 例（0.03%）被诊断为血管内乳头状内皮细胞增生。患者平均年龄为 46.55 岁，女性（12 例/60%）受影响更为严重。下嘴唇（9 例/47.36%）是最常受影响的部位，病变通常无症状（7 例/63.63%）。临床上，90%的病变（18 例）表现为结节，平均大小为 1.13cm。最常提出的临床诊断假设是黏液囊肿（6 例/37.50%）和血管瘤（5 例/31.25%）。所有病例均选择切除活检进行治疗。系统回顾纳入了 49 项研究，共 105 例。文献中的所有变量均显示出相似性。
尽管罕见，但临床医生和口腔病理学家应该熟悉血管内乳头状内皮细胞增生与其他一些病变在临床和组织学特征方面的相似之处。
