Montorio Daniela, D'Andrea Luca, Mirto Nicola, Cennamo Gilda
Department of Neurosciences, Reproductive and Dentistry Sciences, University of Naples Federico II, Naples, Italy.
Eye Clinic, Public Health Department, University of Naples Federico II, Via S. Pansini 5, 80133 Naples, Italy.
Photodiagnosis Photodyn Ther. 2021 Mar;33:102094. doi: 10.1016/j.pdpdt.2020.102094. Epub 2020 Nov 11.
To investigate the changes in retinal and choriocapillaris vessel density (VD) in patients effected by early age-related macular degeneration (AMD) and reticular pseudodrusen (RPD), using Optical Coherence Tomography Angiography (OCTA).
A total of seventy-eight eyes of 78 patients (43 male, 35 female, mean age 72.61 ± 5.15) with non-neovascular AMD (38 eyes with early AMD and 40 eyes with RPD) was recruited in this observational prospective study. Forty eyes of 40 healthy subjects represented the control group. The VD was measured in superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris in different macular regions.
There were no significant differences in VD of the SCP and DCP among the controls and the two study groups (p > 0.05). The VD of the choriocapillaris revealed a statistically significant reduction in early AMD and RPD groups respect to controls (p < 0.001). Furthermore, the patients with RPD showed a significantly decreased VD respect to patients with early AMD in different macular regions (p < 0.001).
The quantitative analysis of retinal and choriocapillaris blood flow by OCTA provided useful information regarding the vascular changes in non-neovascular AMD patients suggesting that the choriocapillaris loss is mainly involved in the pathogenesis of RPD.
采用光学相干断层扫描血管造影（OCTA）技术，研究早期年龄相关性黄斑变性（AMD）和网状假性玻璃膜疣（RPD）患者视网膜及脉络膜毛细血管血管密度（VD）的变化。
本前瞻性观察研究纳入了78例患者的78只眼（男性43例，女性35例，平均年龄72.61±5.15岁），其中非新生血管性AMD患者38眼（早期AMD），RPD患者40眼。40例健康受试者的40只眼作为对照组。测量不同黄斑区域浅表毛细血管丛（SCP）、深部毛细血管丛（DCP）和脉络膜毛细血管的VD。
对照组与两个研究组之间，SCP和DCP的VD无显著差异（p>0.05）。早期AMD组和RPD组脉络膜毛细血管的VD与对照组相比有统计学显著降低（p<0.001）。此外，RPD患者在不同黄斑区域的VD相对于早期AMD患者显著降低（p<0.001）。
OCTA对视网膜和脉络膜毛细血管血流的定量分析为非新生血管性AMD患者的血管变化提供了有用信息，提示脉络膜毛细血管丧失主要参与RPD的发病机制。
