Ophthalmology Unit, Neurosciences, Mental Health, and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, University of Rome Sapienza, Rome, Italy.
St. Andrea Hospital, Via di Grottarossa 1035/1039, Rome, Italy.
Eye (Lond). 2024 Jan;38(1):173-178. doi: 10.1038/s41433-023-02654-1. Epub 2023 Jul 7.
BACKGROUND/OBJECTIVES: Microvascular alterations and choroidal impairment are emerging as a pathologic pathway in age-related macular degeneration (AMD). This study aimed to evaluate the central macular choriocapillaris (CC) in eyes with subretinal drusenoid deposits (SDD) and the retinal microvasculature in patients with early AMD phenotypes.
SUBJECTS/METHODS: This was an institutional, multicentric observational cross-sectional study. Ninety-nine eyes of 99 subjects; 33 eyes with SDD only, 33 eyes with conventional drusen (CD) only, and 33 eyes of healthy age-matched subjects were included. Comprehensive ophthalmologic examination and optical coherence tomography angiography (OCTA) was performed. The central macular flow area of the CC was analysed in the SDD group and the vessel density of the retinal superficial capillary plexus (SCP) and deep capillary plexus (DCP) was analysed in the SDD and CD groups using automated OCTA output parameters.
The flow area of the CC in the SDD group was significantly reduced (p ≤ 0.001) with respect to the healthy control group. There was a trend of reduction of vessel density of the SCP and the DCP in the SDD and CD group with respect to controls, although this did not reach statistical significance.
OCTA data in the present report corroborate the role of vascular damage in early AMD with CC impairment in the central macular area in eyes with SDD.
背景/目的：微血管改变和脉络膜损伤正在成为年龄相关性黄斑变性（AMD）的病理途径。本研究旨在评估具有视网膜下类脂沉积（SDD）的眼中的中心黄斑脉络膜毛细血管（CC）和具有早期 AMD 表型的患者的视网膜微血管。
受试者/方法：这是一项机构性、多中心观察性横断面研究。纳入 99 名受试者的 99 只眼；33 只眼仅为 SDD，33 只眼仅为常规玻璃膜疣（CD），33 只眼为年龄匹配的健康对照。进行全面眼科检查和光相干断层扫描血管造影（OCTA）。在 SDD 组中分析中央黄斑 CC 的血流面积，在 SDD 和 CD 组中分析视网膜浅层毛细血管丛（SCP）和深层毛细血管丛（DCP）的血管密度，使用自动 OCTA 输出参数。
SDD 组的 CC 血流面积明显减少（p≤0.001），与健康对照组相比。SDD 和 CD 组的 SCP 和 DCP 的血管密度有减少的趋势，但与对照组相比无统计学意义。
本报告的 OCTA 数据证实了血管损伤在 SDD 眼中早期 AMD 中的作用，以及中央黄斑区 CC 损伤。
