辐射对胃肠道癌患者血浆中前列环素生物半衰期的影响。
The influence of irradiation on the biological half-life of prostacyclin in plasma of patients with gastrointestinal cancer.
作者信息
Polterauer P, Sinzinger H, Peskar B A
机构信息
Second Department of Gastroenterology and Hepatology, University of Vienna, Austria.
出版信息
Br J Exp Pathol. 1987 Oct;68(5):637-42.
In seven patients suffering from inoperable pancreatic cancer and in 14 patients with inoperable colonic cancer the half-life (T/2) of prostaglandin (PG)I2 in plasma in vitro has been determined before and at various intervals after irradiation. No significant difference of PGI2-T/2 could be observed either before irradiation, at the end of the irradiation period or 3 and 6 weeks after the last irradiation. Thus irradiation does not appear to interfere with the degradation of PGI2-T/2 in plasma. In patients with inoperable pancreatic and colonic cancer the PGI2-T/2 was not significantly different to that of the PGI2-T/2 of controls. Thus, a shortening of PGI2-T/2 is not a common feature in tumour patients. Hyperaggregation promoting seeding of metastases is not influenced by irradiation via the particular parameter of the PG-system.
在7例患有无法手术切除的胰腺癌患者和14例患有无法手术切除的结肠癌患者中，测定了放疗前及放疗后不同时间点血浆中前列腺素（PG）I2的体外半衰期（T/2）。在放疗前、放疗结束时以及最后一次放疗后3周和6周，均未观察到PGI2-T/2有显著差异。因此，放疗似乎不会干扰血浆中PGI2-T/2的降解。在患有无法手术切除的胰腺癌和结肠癌患者中，PGI2-T/2与对照组的PGI2-T/2无显著差异。因此，PGI2-T/2缩短并非肿瘤患者的常见特征。促进转移播散的血小板过度聚集不受通过PG系统特定参数进行的放疗影响。
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