[前列腺素系统的缺陷。V. 血浆中前列环素降解的遗传性（？）疾病（维也纳 - 德布林缺陷）]
[Defects in the prostaglandin system. V. Inherited (?) disorder of prostacyclin degradation in the plasma (Wien-Döbling defect)].
作者信息
Sinzinger H, Fitscha P, Peskar B A
出版信息
Wien Klin Wochenschr. 1985 Sep 27;97(18):726-9.
PMID:3907156
Abstract
The case report is presented of a woman of child-bearing age who developed myocardial infarction. An extremely shortened in vitro half-life of PGI2 in plasma was detected in this patient. This new familial defect "Wien-Döbling", in the prostaglandin system might affect an essential coregulator of haemostatic balance in man. It is not known whether this short half-life of PGI2 in vitro is due to accelerated degradation or a failure in stabilization of this biologically active compound.
摘要
本文报告了一例育龄期女性发生心肌梗死的病例。该患者血浆中前列环素（PGI2）的体外半衰期极短。前列腺素系统中这种新的家族性缺陷“维也纳-多布林”可能会影响人体止血平衡的一种重要协同调节因子。目前尚不清楚PGI2体外半衰期短是由于其降解加速还是这种生物活性化合物的稳定化失败所致。
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The influence of irradiation on the biological half-life of prostacyclin in plasma of patients with gastrointestinal cancer.辐射对胃肠道癌患者血浆中前列环素生物半衰期的影响。
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