Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of Agricultural Products, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China; Department of Food Science, University of Massachusetts, Amherst, MA 01003, United States.
Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of Agricultural Products, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China.
Food Chem. 2021 Apr 16;342:128536. doi: 10.1016/j.foodchem.2020.128536. Epub 2020 Nov 4.
Shepherd's purse as a wild vegetable is getting more and more attention on health benefits. Water extract of shepherd's purse (WESP) was prepared and analyzed for the chemical constituents. The mice were fed high-fructose (HF) diet and treated with WESP at 50, 100 and 200 mg/kg·bw for 8 weeks. The HF-fed mice receiving WESP exhibited the inhibitions against abnormal weight gain, hepatic fat accumulation and lipid metabolic by down-regulating FAS and ACC expressions. WESP also significantly alleviated hyperglycemia, oxidative stress, and inflammatory response by regulating of NF-κB pathway. Moreover, WESP dose-dependently increased the acetic, propionic, and butyric acids levels in HF-fed mice. Furthermore, WESP significantly alleviated the HF-induced gut dysbiosis by reducing the ratio of Firmicutes to Bacteroidetes and increasing the abundance of potential beneficial bacteria. Our findings indicate that WESP may be an effective dietary supplement for preventing the liver damage.
荠菜作为一种野生蔬菜，其对健康的益处越来越受到关注。本研究制备并分析了荠菜水提物（WESP）的化学成分。将小鼠用高果糖（HF）饮食喂养，并以 50、100 和 200mg/kg·bw 的剂量用 WESP 处理 8 周。结果显示，WESP 可抑制 HF 喂养小鼠体重异常增加、肝脂肪堆积和脂质代谢，下调 FAS 和 ACC 的表达。WESP 通过调节 NF-κB 通路，还显著减轻了高血糖、氧化应激和炎症反应。此外，WESP 还可剂量依赖性地增加 HF 喂养小鼠体内的乙酸、丙酸和丁酸水平。此外，WESP 通过降低厚壁菌门与拟杆菌门的比例和增加潜在有益细菌的丰度，显著缓解了 HF 引起的肠道菌群失调。我们的研究结果表明，WESP 可能是一种有效的膳食补充剂，可预防肝脏损伤。
