Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ont.
Department of Ophthalmology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ont.
Can J Ophthalmol. 2021 Jun;56(3):151-157. doi: 10.1016/j.jcjo.2020.10.014. Epub 2020 Nov 12.
Quality of vision plays an important role in everyday living, and low vision (LV) can take a toll on individual's quality of life (QOL). The objective of this paper is to evaluate the impact of LV on QOL and depressive symptoms in LV patients compared with healthy controls.
Systematic review and meta-analysis.
Literature was systematically searched to obtain all relevant records. Covidence software was used to conduct the systematic review. Duplicate records were removed, and 2 independent reviewers screened records for relevance. After screening, risk of bias assessment was carried out. Data were extracted and meta-analysis was performed using STATA 15.0. Fixed-effect and random-effect models were computed based on heterogeneity.
In total, 2870 records were retrieved from database and grey literature searches. Twelve articles (35 341 subjects) were included for quantitative analysis. Overall, the QOL of LV patients was significantly lower compared with healthy individuals. Common QOL questionnaires, including 25-item visual function questionnaire (VFQ-25) (standard mean difference [SMD] = 0.91, confidence interval [CI]: [0.42-1.40]), 36-item short form survey (SMD = 0.53, CI: [0.26-0.80]), VFQ-14 (SMD = 0.58, CI: [0.42-0.74]), and visual function QOL questionnaire (SMD = 0.68, CI: [0.54-0.82]), demonstrated a poor QOL in LV patients compared with healthy controls. Additionally, odds of depressive symptoms were significantly greater (odds ratio = 2.25, CI: [1.58-3.21]) in LV patients compared with controls.
LV patients demonstrated a poor QOL and higher odds of depressive symptoms compared with healthy controls.
视力质量在日常生活中起着重要作用，低视力（LV）会降低个人的生活质量（QOL）。本文旨在评估 LV 对 LV 患者与健康对照者 QOL 和抑郁症状的影响。
系统评价和荟萃分析。
系统检索文献以获取所有相关记录。使用 Covidence 软件进行系统评价。去除重复记录，由 2 名独立审查员筛选记录的相关性。筛选后，进行偏倚风险评估。使用 STATA 15.0 提取数据并进行荟萃分析。根据异质性，计算固定效应和随机效应模型。
从数据库和灰色文献搜索中检索到 2870 条记录。纳入 12 篇文章（35341 名受试者）进行定量分析。总体而言，LV 患者的 QOL 明显低于健康个体。常见的 QOL 问卷，包括 25 项视觉功能问卷（VFQ-25）（标准均数差 [SMD] = 0.91，置信区间 [CI]：[0.42-1.40]）、36 项简短形式调查（SMD = 0.53，CI：[0.26-0.80]）、VFQ-14（SMD = 0.58，CI：[0.42-0.74]）和视觉功能 QOL 问卷（SMD = 0.68，CI：[0.54-0.82]），表明 LV 患者的 QOL 较差。此外，LV 患者出现抑郁症状的几率明显更高（比值比 [OR] = 2.25，CI：[1.58-3.21]）。
与健康对照者相比，LV 患者的 QOL 较差，抑郁症状的几率更高。
