Jáuregui-Renaud Kathrine, Miguel-Puga José Adan, García-López Aida, Tirado-Mondragón María de Lourdes, Figueroa-Padilla Ignacio, Lara-Angeles Nayeli Scarlett, Chávez-Navarrete Olimpia
Unidad de Investigación Médica en Otoneurología, Instituto Mexicano del Seguro Social, Ciudad de México, México.
Hospital General de Zona 8, Instituto Mexicano del Seguro Social, Ciudad de México, México.
Sci Rep. 2025 Aug 14;15(1):29812. doi: 10.1038/s41598-025-13356-x.
Two hundred and one adults aged 28 to 80 years (100 without/101 with type 2 diabetes) participated in a cross sectional study to assess the correlation among sensory deficits, depersonalization/derealization, and anxiety/depression symptoms and their contribution to health-related quality of life, considering individual characteristics (age, sex, obesity, COVID-19 history). Assessments included: general health, body mass index, sensory deficits (vision/neuropathy/hearing/vestibular), symptoms related to balance, dissociative experiences, depersonalization/derealization and anxiety/depression symptoms, and health-related quality of life. Analyses were performed by bivariate and covariance tests (p ≤ 0.05). Participants with diabetes exhibited multisensory deficits and increased mental symptoms, with reduced health-related quality of life. Anxiety/depression symptoms were mainly related to balance symptoms, significant dissociative experiences and obesity (adjusted R = 0.20, p < 0.000001); depersonalization/derealization symptoms were mainly related to sensory deficits, balance and anxiety/depression symptoms (adjusted R = 0.48, p < 0.000001). The majority of these variables, along with age contributed to the variance on health-related quality of life (adjusted R = 0.43, p < 0.000001). The results support that the sensory deficits related to diabetes may reduce the perceived health-related quality of life by both physical and mental aftereffects, including unreality perceptions; the multisensory integration required for balance may have a particular role on mental health and functioning; assessment of depersonalization/derealization symptoms requires considering sensory deficits.
201名年龄在28至80岁之间的成年人（100名无2型糖尿病/101名有2型糖尿病）参与了一项横断面研究，以评估感觉缺陷、人格解体/现实解体与焦虑/抑郁症状之间的相关性，以及它们对健康相关生活质量的影响，并考虑个体特征（年龄、性别、肥胖、新冠病史）。评估内容包括：总体健康状况、体重指数、感觉缺陷（视力/神经病变/听力/前庭功能）、与平衡相关的症状、解离体验、人格解体/现实解体和焦虑/抑郁症状，以及健康相关生活质量。分析采用双变量和协方差检验（p≤0.05）。糖尿病患者表现出多感觉缺陷和精神症状增加，健康相关生活质量降低。焦虑/抑郁症状主要与平衡症状、显著的解离体验和肥胖有关（调整后R=0.20，p<0.000001）；人格解体/现实解体症状主要与感觉缺陷、平衡和焦虑/抑郁症状有关（调整后R=0.48，p<0.000001）。这些变量中的大多数，连同年龄，对健康相关生活质量的方差有贡献（调整后R=0.43，p<0.000001）。结果支持，与糖尿病相关的感觉缺陷可能通过身心后遗症，包括虚幻感，降低感知的健康相关生活质量；平衡所需的多感觉整合可能对心理健康和功能有特殊作用；对人格解体/现实解体症状的评估需要考虑感觉缺陷。
