Neukirch F, Maccario J, Korobaeff M, Annesi I, Liard R, Orvoen-Frija E, Kauffmann F
INSERM U 179, Le Vésinet, France.
Bull Eur Physiopathol Respir. 1987 Jul-Aug;23(4):383-6.
The object of the study was to find a model to summarize all the information from dose-response curves, by determining the coefficients to be used to compare groups of subjects. Three coefficients were calculated from the following model: F(d)/F(o) = ONE - k(d-delta)alpha+, where F(d)/F(o) was the ratio between FEV1 at dose (d) of methacholine and prechallenge FEV1, 'k' the slope of the relative variation of FEV1 with the dose, 'delta' the threshold dose and 'alpha' a shape factor. The model was applied to the study of hyperresponsiveness in a population of 317 men. The results illustrated the interest of this model which was applicable to 91% of the population and permitted fine discrimination of the groups studied.
该研究的目的是找到一个模型，通过确定用于比较受试者组的系数来总结剂量反应曲线中的所有信息。从以下模型计算出三个系数：F(d)/F(o) = 1 - k(d - δ)α+，其中F(d)/F(o)是乙酰甲胆碱剂量为(d)时的第一秒用力呼气容积(FEV1)与激发前FEV1的比值，“k”是FEV1随剂量的相对变化斜率，“δ”是阈值剂量，“α”是形状因子。该模型应用于对317名男性人群的高反应性研究。结果表明该模型具有实用性，它适用于91%的人群，并能对所研究的组进行精细区分。
