Uppal Gurdip, Bahcecioglu Gokhan, Zorlutuna Pinar, Vural Dervis Can
Department of Physics, University of Notre Dame, Notre Dame, Indiana.
Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, Indiana.
Biophys J. 2020 Dec 15;119(12):2573-2583. doi: 10.1016/j.bpj.2020.11.004. Epub 2020 Nov 13.
Aging is driven by subcellular processes that are relatively well understood. However, the qualitative mechanisms and quantitative dynamics of how these micro-level failures cascade to a macro-level catastrophe in a tissue or organs remain largely unexplored. Here, we experimentally and theoretically study how cell failure propagates in an engineered tissue in the presence of advective flow. We argue that cells secrete cooperative factors, thereby forming a network of interdependence governed by diffusion and flow, which fails with a propagating front parallel to advective circulation.
衰老由相对已被充分理解的亚细胞过程驱动。然而，这些微观层面的故障如何在组织或器官中级联成宏观层面的灾难的定性机制和定量动态在很大程度上仍未被探索。在这里，我们通过实验和理论研究了在存在平流的情况下细胞故障如何在工程组织中传播。我们认为细胞分泌协同因子，从而形成一个由扩散和流动控制的相互依存网络，该网络会随着与平流循环平行的传播前沿而失效。
