Neuroscience Department, Westminster College, New Wilmington, PA 16172.
Neuroscience Department, Westminster College, New Wilmington, PA 16172.
Physiol Behav. 2021 Mar 1;230:113246. doi: 10.1016/j.physbeh.2020.113246. Epub 2020 Nov 12.
Pharmacological agents that treat anxiety disorders are often validated in animal models prior to clinical trials. Yet results suggest little consistency in rodent anxiety-like behavior across tests. The current study examined the relationship between anxiety-like behaviors of male rats in the open field test and free exploratory paradigm. Results indicate most anxiety-like behaviors between tests were not correlated and few correlations existed within tests, despite similarity in testing apparatus, procedures, and quantified behaviors. These results suggest even very similar tests may provide insight into different facets of anxiety and urge caution when translating animal results to the human condition.
治疗焦虑症的药物通常在临床试验之前在动物模型中进行验证。然而，研究结果表明，在不同的测试中，啮齿类动物的焦虑样行为表现出很小的一致性。本研究考察了雄性大鼠在旷场试验和自由探索范式中的焦虑样行为之间的关系。结果表明，尽管测试仪器、程序和量化行为相似，但大多数测试之间的焦虑样行为没有相关性，很少有测试内存在相关性。这些结果表明，即使是非常相似的测试也可能提供对焦虑不同方面的深入了解，并在将动物结果转化为人类状况时提醒谨慎。
