Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Piazza Miraglia, 2, 80138 Naples, Italy.
Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Piazza Miraglia, 2, 80138 Naples, Italy.
Front Neuroendocrinol. 2021 Jan;60:100889. doi: 10.1016/j.yfrne.2020.100889. Epub 2020 Nov 12.
Multiple Sclerosis is a multifactorial chronic autoimmune disease, affecting predominantly females in the fertile age. Sex hormones changes during a woman's life, from puberty to menopause, including pregnancy and puerperium, may influence the onset and course of Multiple Sclerosis. The effect of estrogen levels on immune, clinical and radiological aspects of Multiple Sclerosis, also stimulated investigation on the effect of sexual hormones therapies, such as oral contraceptives and assisted reproductive technique, on the Multiple Sclerosis course.
A literature search for original articles and reviews was conducted in the databases, including PubMed, Scopus, and ClinicalTrials.gov of the U.S. National Library of Medicine site from 1988 to 2020.
This review reports the effects of the physiological and iatrogenic hormonal changes either on immune or clinical or paraclinical features in the different life stages of women affected by Multiple Sclerosis.
多发性硬化症是一种多因素的慢性自身免疫性疾病，主要影响育龄期女性。女性在生命过程中会经历多种生理变化，包括青春期、绝经期、怀孕期和产褥期，这些变化可能会影响多发性硬化症的发病和病程。雌激素水平对多发性硬化症免疫、临床和影像学方面的影响，也促使人们研究性激素治疗（如口服避孕药和辅助生殖技术）对多发性硬化症病程的影响。
对美国国立医学图书馆的数据库，包括 PubMed、Scopus 和 ClinicalTrials.gov 中的原始文章和综述进行了文献检索，检索时间从 1988 年至 2020 年。
本综述报告了女性在不同生命阶段中，生理性和医源性激素变化对多发性硬化症患者免疫、临床或临床前特征的影响。
