Division of Molecular Pathology, The Institute of Cancer Research, London, UK.
Br J Haematol. 2020 Nov;191(4):535-541. doi: 10.1111/bjh.17159.
This is an historical account of the randomised trials in chronic lymphocytic leukaemia in the UK between the years 1978 to 2004, describing their gestation, the treatments used and the main lessons learnt. Those lessons include: (1) how best to use chlorambucil, which was the first effective treatment for CLL; (2) the significant difference in survival between the sexes; and (3) the value of prognostic markers, both morphological and molecular, which continue to be relevant to current practice.
这是一篇关于 1978 年至 2004 年英国慢性淋巴细胞白血病随机临床试验的历史记录，描述了它们的孕育、所使用的治疗方法以及主要经验教训。这些经验教训包括：（1）如何最好地使用苯丁酸氮芥，这是治疗 CLL 的第一种有效药物；（2）性别对生存率的显著影响；（3）形态学和分子预后标志物的价值，这些标志物对当前的实践仍然具有重要意义。
