Rai K R
Albert Einstein College of Medicine, NY.
Baillieres Clin Haematol. 1993 Dec;6(4):757-65. doi: 10.1016/s0950-3536(05)80174-x.
A historical review of gains in the body of knowledge on chronic lymphocytic leukaemia (CLL) reveals a continuous, steady process from the beginning of the century with the pioneering work of scholars to the present era of molecular biology. Several notable hallmarks of this progress have been recognized: (1) the early period of broad, loose grouping of all chronic lymphoproliferative disorders; (2) recognition of CLL as a discrete entity with clinical and cytological identification of different forms of lymphoid neoplasm; (3) development of clinical staging systems and prognostic factors; and (4) use of immunological techniques in the study of CLL. Studies currently in progress using molecular genetic techniques hold promise for future advances in unravelling the biology of leukaemic transformation of lymphocytes in CLL.
对慢性淋巴细胞白血病（CLL）知识体系发展的历史回顾显示，从本世纪初学者们的开创性工作到如今的分子生物学时代，这是一个持续、稳定的过程。这一进展有几个显著标志：（1）所有慢性淋巴细胞增殖性疾病广泛、松散分类的早期阶段；（2）将CLL识别为一种离散实体，并通过临床和细胞学方法鉴别不同形式的淋巴样肿瘤；（3）临床分期系统和预后因素的发展；以及（4）在CLL研究中使用免疫技术。目前正在进行的利用分子遗传学技术的研究有望在未来进一步揭示CLL中淋巴细胞白血病转化的生物学机制。
