Motoyama Kahoko, Isojima Tsuyoshi, Sato Yasuhiro, Aihara Ayaka, Asakura Hitomi, Hiraike Haruko, Hino Yuko, Mimaki Masakazu, Nomura Kyoko, Kodama Hiroko
Department of Pediatrics, Teikyo University School of Medicine, Tokyo, Japan.
Department of Nutrition, Teikyo University Hospital, Tokyo, Japan.
Pediatr Int. 2021 Aug;63(8):910-917. doi: 10.1111/ped.14543. Epub 2021 Aug 2.
Many trace elements are essential for infant growth and development during early life. Their concentrations in breast milk vary depending on social and economic factors. Nonetheless, the present available values in Japan were derived from lactating mothers approximately 15 years ago.
Healthy mothers who gave birth to a single infant after 37 weeks of gestation at Teikyo University Hospital were recruited between July 2016 and December 2017. They were encouraged to collect breast milk samples and a self-administered food frequency questionnaire at 1 and 3 months postpartum. Anthropometric data for the mothers and their infants were also collected. Overall, 79 subjects were analyzed after excluding subjects with inadequate data in the food frequency questionnaire, insufficient breast milk samples, and medication that could affect dietary intakes. Trace element concentrations were determined by inductively coupled plasma mass spectrometry, and their correlation with several factors were investigated.
Trace element concentrations were widely distributed as previously reported. Median concentrations of Cr, Mn, Fe, Cu, Zn, Se, and Mo were 0.8, 0.8, 98, 50, 272, 2.2, and 0.7 µg/dL at 1 month postpartum and 0.6, 0.7, 55, 33, 177, 2.1, and 0.7 µg/dL at 3 months postpartum, respectively. There were no correlations between trace element concentrations and either mothers' intakes or infants' growth. In contrast, there were significant correlations between several trace elements and macronutrients in addition to inter-element correlations among almost all trace elements.
Trace element concentrations in mature breast milk were determined from recently lactating mothers in Japan.
许多微量元素对婴儿早期的生长发育至关重要。母乳中这些元素的浓度因社会和经济因素而异。尽管如此，日本目前可用的值大约是15年前从哺乳期母亲那里获得的。
2016年7月至2017年12月期间，在帝京大学医院招募了妊娠37周后分娩单胎婴儿的健康母亲。鼓励她们在产后1个月和3个月收集母乳样本和自行填写的食物频率问卷。还收集了母亲及其婴儿的人体测量数据。总体而言，在排除食物频率问卷数据不充分、母乳样本不足以及可能影响饮食摄入的药物治疗的受试者后，对79名受试者进行了分析。通过电感耦合等离子体质谱法测定微量元素浓度，并研究其与多种因素的相关性。
如先前报道，微量元素浓度分布广泛。产后1个月时，铬、锰、铁、铜、锌、硒和钼的中位数浓度分别为0.8、0.8、98、50、272、2.2和0.7μg/dL，产后3个月时分别为0.6、0.7、55、33、177、2.1和0.7μg/dL。微量元素浓度与母亲的摄入量或婴儿的生长均无相关性。相比之下，除了几乎所有微量元素之间的元素间相关性外，几种微量元素与常量营养素之间存在显著相关性。
在日本，从近期哺乳期母亲中测定了成熟母乳中的微量元素浓度。
