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父母收入作为儿童期社会经济地位的标志物,以及在全诊断谱系中研究后来发生二级保健诊断的精神障碍的风险:一项全国队列研究。

Parental income as a marker for socioeconomic position during childhood and later risk of developing a secondary care-diagnosed mental disorder examined across the full diagnostic spectrum: a national cohort study.

机构信息

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, P.O. Box 21, 00014, Helsinki, Finland.

Centre for Pharmacoepidemiology and Drug Safety, Division of Pharmacy and Optometry, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK.

出版信息

BMC Med. 2020 Nov 16;18(1):323. doi: 10.1186/s12916-020-01794-5.

Abstract

BACKGROUND

Links between parental socioeconomic position during childhood and subsequent risks of developing mental disorders have rarely been examined across the diagnostic spectrum. We conducted a comprehensive analysis of parental income level, including income mobility, during childhood and risks for developing mental disorders diagnosed in secondary care in young adulthood.

METHODS

National cohort study of persons born in Denmark 1980-2000 (N = 1,051,265). Parental income was measured during birth year and at ages 5, 10 and 15. Follow-up began from 15th birthday until mental disorder diagnosis or 31 December 2016, whichever occurred first. Hazard ratios and cumulative incidence were estimated.

RESULTS

A quarter (25.2%; 95% CI 24.8-25.6%) of children born in the lowest income quintile families will have a secondary care-diagnosed mental disorder by age 37, versus 13.5% (13.2-13.9%) of those born in the highest income quintile. Longer time spent living in low-income families was associated with higher risks of developing mental disorders. Associations were strongest for substance misuse and personality disorders and weaker for mood disorders and anxiety/somatoform disorders. An exception was eating disorders, with low parental income being associated with attenuated risk. For all diagnostic categories examined except for eating disorders, downward socioeconomic mobility was linked with higher subsequent risk and upward socioeconomic mobility with lower subsequent risk of developing mental disorders.

CONCLUSIONS

Except for eating disorders, low parental income during childhood is associated with subsequent increased risk of mental disorders diagnosed in secondary care across the diagnostic spectrum. Early interventions to mitigate the disadvantages linked with low income, and better opportunities for upward socioeconomic mobility could reduce social and mental health inequalities.

摘要

背景

儿童时期父母的社会经济地位与随后发展为精神障碍的风险之间的联系很少在整个诊断谱系中进行研究。我们对儿童时期父母的收入水平(包括收入流动性)进行了全面分析,并评估了其与青年期在二级保健中诊断出的精神障碍风险之间的关系。

方法

对丹麦 1980-2000 年出生的人群进行全国队列研究(n=1051265)。父母的收入在出生年份以及 5、10 和 15 岁时进行测量。随访从 15 岁生日开始,直至精神障碍诊断或 2016 年 12 月 31 日,以先发生者为准。使用风险比和累积发病率进行评估。

结果

在收入最低五分位家庭中出生的儿童中,有四分之一(25.2%;95%CI 24.8-25.6%)会在 37 岁前被二级保健机构诊断为精神障碍,而在收入最高五分位家庭中出生的儿童中这一比例为 13.5%(13.2-13.9%)。在低收入家庭中生活的时间越长,患精神障碍的风险就越高。这种关联在物质使用障碍和人格障碍中最强,而在心境障碍和焦虑/躯体形式障碍中较弱。一个例外是饮食障碍,低父母收入与风险降低有关。除了饮食障碍,所有研究的诊断类别中,社会经济地位下降与二级保健诊断的精神障碍的后续风险增加有关,而社会经济地位上升与精神障碍的后续风险降低有关。

结论

除了饮食障碍,儿童时期父母收入低与二级保健诊断的精神障碍的后续风险增加有关,横跨整个诊断谱系。早期干预可以减轻与低收入相关的劣势,并为向上的社会经济流动提供更好的机会,从而减少社会和心理健康方面的不平等。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b57f/7667856/07285cff788f/12916_2020_1794_Fig1_HTML.jpg

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