Advanced Radiation Oncology Department, IRCCS Sacro Cuore Don Calabria Hospital, Cancer Care Center, via Don Sempreboni 5, 37034 Verona, Negrar, Italy.
Unit of Neurosurgery, Department of Neurosciences, Hospital Trust of Verona, Verona, Italy.
Neurochirurgie. 2021 Apr;67(2):193-197. doi: 10.1016/j.neuchi.2020.10.002. Epub 2020 Oct 22.
A 55-year old man with a history of meningioma treated with LHRH-agonist plus radiotherapy for prostate cancer (PCa) experienced a meningioma growth during hormone therapy (HT). Meningioma was radically resected revealing an atypical meningioma and HT was continued due to the high risk of PCa relapse until symptomatic meningioma relapse occurred after further 10 months. Gross lesions were radically removed and histology revealed anaplastic meningioma. This is the first case of rapid meningioma evolution to an anaplastic histology during LHRH-agonist.
一位 55 岁男性，曾因前列腺癌（PCa）接受 LHRH 激动剂加放疗治疗脑膜瘤。在激素治疗（HT）期间，该患者经历了脑膜瘤生长。脑膜瘤被彻底切除，显示为非典型脑膜瘤，由于 PCa 复发的高风险，HT 继续进行，直到进一步的 10 个月后出现症状性脑膜瘤复发。大体病变被彻底切除，组织学显示为间变性脑膜瘤。这是首例在 LHRH 激动剂治疗期间快速演变至间变性组织学的脑膜瘤病例。
