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成功使用贝那鲁肽治疗日本西部灾难性暴雨后发生的变应性支气管肺曲霉病。

Successful Treatment with Benralizumab for Allergic Bronchopulmonary Aspergillosis That Developed after Disastrous Heavy Rainfall in Western Japan.

机构信息

Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan.

出版信息

Intern Med. 2021 May 1;60(9):1443-1450. doi: 10.2169/internalmedicine.6217-20. Epub 2020 Nov 16.

Abstract

We herein report a 56-year-old woman who developed allergic bronchopulmonary aspergillosis (ABPA) possibly due to fungal exposure after disastrous heavy rainfall in Western Japan in 2018. She was diagnosed with ABPA complicated with asthma, increased peripheral blood eosinophil count, elevation of specific immunoglobulin E for Aspergillus fumigatus, positive Aspergillus fumigatus precipitation antibody reaction test results, and notable chest computed tomography findings. After treatment with benralizumab, her symptoms, peripheral blood eosinophil count, radiological findings, and respiratory function dramatically improved. The administration of benralizumab appears to be an effective treatment strategy for ABPA.

摘要

我们在此报告一例 56 岁女性患者,她可能因 2018 年日本西部灾难性暴雨后真菌暴露而发生变应性支气管肺曲霉病(ABPA)。该患者诊断为并发哮喘的 ABPA,伴有外周血嗜酸性粒细胞计数增加、烟曲霉特异性免疫球蛋白 E 升高、烟曲霉沉淀抗体反应试验阳性结果和显著的胸部计算机断层扫描发现。贝那鲁肽治疗后,其症状、外周血嗜酸性粒细胞计数、影像学表现和呼吸功能均显著改善。贝那鲁肽的给药似乎是 ABPA 的一种有效治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa0b/8170259/7609ea728bd9/1349-7235-60-1443-g001.jpg

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