Kingwell B, Fritzler M J, Decoteau J, Rattner J B
Department of Medical Biochemistry, University of Calgary, Alberta, Canada.
Cell Motil Cytoskeleton. 1987;8(4):360-7. doi: 10.1002/cm.970080408.
An autoantibody that binds an antigen localized to the stembody of dividing cells has been identified in a patient with systemic sclerosis. Initially, this antigen is associated with the surface of the metaphase chromosomes. At the onset of anaphase the antigen becomes preferentially associated with the forming stembodies. This association is maintained as furrowing progresses during telophase and continues after the intercellular bridge is released from the daughter cells during G-1. Immunoblots indicate that the epitope detected by immunofluorescence is present on a protein with an apparent molecular weight of 38 kD.
在一名系统性硬化症患者中发现了一种自身抗体，该抗体可结合定位于分裂细胞茎体的抗原。最初，这种抗原与中期染色体的表面相关。在后期开始时，该抗原优先与正在形成的茎体相关。随着末期沟裂的进展，这种关联得以维持，并在G-1期细胞间桥从子细胞释放后继续存在。免疫印迹表明，免疫荧光检测到的表位存在于一种表观分子量为38 kD的蛋白质上。
