Department of Biological Sciences, Indian Institute of Science Education and Research Mohali, Mohali, India.
Biomedical and Diagnostic Sciences, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN, United States.
Front Immunol. 2020 Oct 22;11:581076. doi: 10.3389/fimmu.2020.581076. eCollection 2020.
COVID-19 has become difficult to contain in our interconnected world. In this article, we discuss some approaches that could reduce the consequences of COVID-19. We elaborate upon the utility of camelid single-domain antibodies (sdAbs), also referred to as nanobodies, which are naturally poised to neutralize viruses without enhancing its infectivity. Smaller sized sdAbs can be easily selected using microbes or the subcellular organelle display methods and can neutralize SARS-CoV2 infectivity. We also discuss issues related to their production using scalable platforms. The favorable outcome of the infection is evident in patients when the inflammatory response is adequately curtailed. Therefore, we discuss approaches to mitigate hyperinflammatory reactions initiated by SARS-CoV2 but orchestrated by immune mediators.
在这个相互关联的世界中，COVID-19 已经难以控制。在本文中，我们讨论了一些可能降低 COVID-19 后果的方法。我们详细介绍了骆驼单域抗体（sdAb）的用途，也称为纳米抗体，它们具有天然中和病毒而不增强其感染力的能力。较小的 sdAb 可以使用微生物或亚细胞细胞器展示方法轻松选择，并可以中和 SARS-CoV2 的感染力。我们还讨论了使用可扩展平台生产它们的相关问题。当炎症反应得到充分抑制时，感染的有利结果在患者中是明显的。因此，我们讨论了减轻由 SARS-CoV2 引发但由免疫介质协调的过度炎症反应的方法。
