HOP，一种参与植物应激反应的共伴侣蛋白。
HOP, a Co-chaperone Involved in Response to Stress in Plants.
作者信息
Toribio René, Mangano Silvina, Fernández-Bautista Nuria, Muñoz Alfonso, Castellano M Mar
机构信息
Centro de Biotecnología y Genómica de Plantas, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Universidad Politécnica de Madrid (UPM), Madrid, Spain.
Departamento de Botánica, Ecología y Fisiología Vegetal, Universidad de Córdoba, Córdoba, Spain.
出版信息
Front Plant Sci. 2020 Oct 29;11:591940. doi: 10.3389/fpls.2020.591940. eCollection 2020.
Protein folding is an essential step for protein functionality. In eukaryotes this process is carried out by multiple chaperones that act in a cooperative manner to maintain the proteome homeostasis. Some of these chaperones are assisted during protein folding by different co-chaperones. One of these co-chaperones is HOP, the HSP70-HSP90 organizing protein. This assistant protein, due to its importance, has been deeply analyzed in other eukaryotes, but its function has only recently started to be envisaged in plants. In this kingdom, the role of HOP has been associated to plant response to different cellular, biotic and abiotic stresses. In this article, we analyze the current knowledge about HOP in eukaryotes, paying a special attention to the recently described roles of HOP in plants. In addition, we discuss the recent breakthroughs in the field and the possible new avenues for the study of plant HOP proteins in the future.
蛋白质折叠是蛋白质发挥功能的关键步骤。在真核生物中，这一过程由多种伴侣蛋白协同完成，以维持蛋白质组的稳态。其中一些伴侣蛋白在蛋白质折叠过程中会得到不同共伴侣蛋白的协助。HOP（热休克蛋白70-热休克蛋白90组织蛋白）就是这些共伴侣蛋白之一。由于其重要性，这种辅助蛋白在其他真核生物中已得到深入研究，但直到最近才开始在植物中被认识到其功能。在植物界，HOP的作用与植物对不同细胞、生物和非生物胁迫的反应有关。在本文中，我们分析了目前关于真核生物中HOP的知识，特别关注了HOP在植物中最近被描述的作用。此外，我们还讨论了该领域的最新突破以及未来研究植物HOP蛋白的可能新途径。
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