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吉西他滨诱发的肺炎：一例病例报告及文献综述

Gemcitabine induced pneumonitis: a case report and review of literature.

作者信息

Thalambedu Nishanth, El-Habr Abdallah H

机构信息

Department of Internal Medicine, Abington Jefferson Health, Abington, Pennsylvania, USA.

Department of Pulmonary and Critical Care, Abington Jefferson Health, Abington, Pennsylvania, USA.

出版信息

J Community Hosp Intern Med Perspect. 2020 Oct 29;10(6):579-582. doi: 10.1080/20009666.2020.1811071.

DOI:10.1080/20009666.2020.1811071
PMID:33194133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7598946/
Abstract

We are reporting a case of pneumonitis in an 81 year old-aged woman due to gemcitabine who was successfully managed with steroids. We also reviewed the literature and found previous case reports of gemcitabine induced pneumonitis.We reported this case to alert physicians to be aware of this infrequent and sometimes fatal complication from gemcitabine.

摘要

我们报告了一例81岁老年女性因吉西他滨导致肺炎的病例，该患者通过类固醇治疗成功康复。我们还查阅了文献，发现了之前关于吉西他滨诱发肺炎的病例报告。我们报告此病例是为了提醒医生注意吉西他滨这种罕见且有时会致命的并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aef4/7598946/8daa09493a1b/ZJCH_A_1811071_F0002_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aef4/7598946/45d99d70c713/ZJCH_A_1811071_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aef4/7598946/8daa09493a1b/ZJCH_A_1811071_F0002_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aef4/7598946/45d99d70c713/ZJCH_A_1811071_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aef4/7598946/8daa09493a1b/ZJCH_A_1811071_F0002_B.jpg

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本文引用的文献

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Organizing pneumonia after pancreatic cancer treatment with nab-paclitaxel and gemcitabine: a case report.纳米白蛋白结合型紫杉醇与吉西他滨治疗胰腺癌后出现的机化性肺炎：一例报告
BJR Case Rep. 2018 Feb 5;4(2):20170086. doi: 10.1259/bjrcr.20170086. eCollection 2018.
2
Successful treatment of gemcitabine-induced acute interstitial pneumonia with imatinib mesylate: a case report.甲磺酸伊马替尼成功治疗吉西他滨引起的急性间质性肺炎：1例报告
BMC Cancer. 2016 Oct 12;16(1):793. doi: 10.1186/s12885-016-2833-9.
3
A case series of patients on chemotherapy with dyspnoea and pulmonary infiltrates.
一组接受化疗且出现呼吸困难和肺部浸润的患者病例系列。
BMJ Case Rep. 2013 Jun 5;2013:bcr2013009105. doi: 10.1136/bcr-2013-009105.
4
Increased expression of pro-inflammatory cytokines as a cause of lung toxicity after combined treatment with gemcitabine and thoracic irradiation.吉西他滨与胸部放疗联合治疗后促炎细胞因子表达增加作为肺毒性的一个原因。
Radiother Oncol. 2004 Aug;72(2):231-41. doi: 10.1016/j.radonc.2004.05.004.
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Gemcitabine-induced severe pulmonary toxicity.吉西他滨诱导的严重肺毒性。
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Ara-C lung: noncardiogenic pulmonary edema complicating cytosine arabinoside therapy of leukemia.阿糖胞苷肺：白血病患者接受阿糖胞苷治疗并发的非心源性肺水肿。
Am J Med. 1981 Feb;70(2):256-61. doi: 10.1016/0002-9343(81)90759-2.
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Pulmonary complications of cytosine-arabinoside therapy: radiographic findings.阿糖胞苷治疗的肺部并发症：影像学表现
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