Ullah Khalil, O'Reilly Aine, Power Derek G, O'Connor Terence M
Department of Respiratory Medicine, Mercy University Hospital, Cork, Ireland.
BMJ Case Rep. 2013 Jun 5;2013:bcr2013009105. doi: 10.1136/bcr-2013-009105.
Clinicians often assume that patients who develop pulmonary symptoms and radiographic infiltrates while receiving cytotoxic chemotherapy have opportunistic pulmonary infection or chemotherapy-related interstitial lung disease. We describe two cases of rare complications of commonly used chemotherapeutic agents (gemcitabine-induced eosinophilic pneumonia and rituximab-induced hypersensitivity pneumonitis) that vindicate this assumption but a third case of scleroderma-associated interstitial lung disease that became clinically manifest in a patient who was receiving chemotherapy. The latter case highlights the need for vigilance for other causes of interstitial lung disease in patients receiving chemotherapy.
临床医生通常认为，在接受细胞毒性化疗时出现肺部症状和影像学浸润的患者患有机会性肺部感染或化疗相关的间质性肺病。我们描述了两例常用化疗药物引起的罕见并发症（吉西他滨诱导的嗜酸性粒细胞性肺炎和利妥昔单抗诱导的过敏性肺炎），证实了这一假设，但还有一例硬皮病相关的间质性肺病在一名接受化疗的患者身上临床表现出来。后一例病例凸显了对接受化疗患者的间质性肺病其他病因保持警惕的必要性。
