Sokol R J, Hall P W
Am J Obstet Gynecol. 1977 Sep 15;129(2):208-10. doi: 10.1016/0002-9378(77)90746-3.
The effect, if any, of diabetes mellitus on the fetal renal tubule has not been previously studied. The concentration of beta2 microglobulin in amniotic fluid is a marker of fetal renal tubular function and normally decreases with advancing gestation, implying increasing tubular function. This relationship was found to be disrupted in 12 diabetic pregnancies, suggesting that the fetal renal tubular cell may represent an example of altered fetal functional maturation occurring during diabetic pregnancy.
糖尿病对胎儿肾小管的影响（若有）此前尚未得到研究。羊水β2微球蛋白浓度是胎儿肾小管功能的一个标志物，通常会随着孕周增加而降低，这意味着肾小管功能增强。研究发现，在12例糖尿病妊娠中这种关系受到了干扰，提示胎儿肾小管细胞可能是糖尿病妊娠期间发生的胎儿功能成熟改变的一个例证。
