Takieddine F, Tabbara M, Hall P, Sokol R J, King K C
Acta Obstet Gynecol Scand. 1983;62(4):311-4. doi: 10.3109/00016348309156228.
Beta 2 microglobulin [B2m] and creatinine [Cr] concentrations were measure in the urine of 27 newborn infants. At birth, urinary [B2m] and [B2m]/[Cr] ratios were significantly lower in infants born beyond 36 weeks' gestation. Serial measurements, postnatally, showed a progressive decrease in the urine [B2m]/[Cr] ratio of infants born prematurely. These findings suggest an increase in tubular uptake of B2m with increasing gestational and postnatal age. The current findings tend to support the hypothesis that the decrease in [B2m] observed in amniotic fluid beginning at approximately 36 weeks' gestation reflects maturation of fetal proximal renal tubular function.
对27名新生儿的尿液进行了β2微球蛋白[B2m]和肌酐[Cr]浓度检测。出生时，孕龄超过36周的婴儿尿中[B2m]和[B2m]/[Cr]比值显著较低。出生后的系列检测显示，早产婴儿尿中[B2m]/[Cr]比值逐渐下降。这些发现表明，随着胎龄和出生后年龄的增加，肾小管对B2m的摄取增加。目前的研究结果倾向于支持以下假设：大约从孕36周开始，羊水内观察到的[B2m]下降反映了胎儿近端肾小管功能的成熟。
