雌激素与发育
Estrogens and development.
作者信息
McLachlan J A, Newbold R R
机构信息
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
出版信息
Environ Health Perspect. 1987 Nov;75:25-7. doi: 10.1289/ehp.877525.
Abstract
The normal development of the genital organs of mammals, including humans, is under hormonal control. A role for the female sex hormone estrogen in this process is still unclear. However, exposure of experimental animals or humans to the potent exogenous estrogen, diethylstilbestrol (DES), results in persistent differentiation effects. Since many chemicals in the environment are weakly estrogenic, the possibility of hormonally altered differentiation must be considered.
摘要
包括人类在内的哺乳动物生殖器官的正常发育受激素控制。雌性性激素雌激素在此过程中的作用仍不清楚。然而，实验动物或人类接触强效外源性雌激素己烯雌酚（DES）会导致持续的分化效应。由于环境中的许多化学物质具有弱雌激素性，因此必须考虑激素改变分化的可能性。
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