Yang Meng, Ma Feng, Guan Min
Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Biochemistry and Molecular Biology, Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China.
Center for Human Tissues and Organs Degeneration, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Metabolites. 2021 May 17;11(5):320. doi: 10.3390/metabo11050320.
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and may progress to cirrhosis or even hepatocellular carcinoma. A number of steroid hormones are important regulators of lipid homeostasis through fine tuning the expression of genes related to lipid synthesis, export, and metabolism. Dysregulation of such pathways has been implicated in the pathogenesis of NAFLD. The aim of this review is to clarify the potential impact of steroid hormones on NAFLD. We also highlight potential interventions through modulating steroid hormone levels or the activities of their cognate receptors as therapeutic strategies for preventing NAFLD.
非酒精性脂肪性肝病（NAFLD）是慢性肝病最常见的病因，可能进展为肝硬化甚至肝细胞癌。多种甾体激素通过微调与脂质合成、输出及代谢相关基因的表达，成为脂质稳态的重要调节因子。此类途径的失调与NAFLD的发病机制有关。本综述旨在阐明甾体激素对NAFLD的潜在影响。我们还强调了通过调节甾体激素水平或其同源受体的活性作为预防NAFLD的治疗策略的潜在干预措施。
