Snoeij N J, Penninks A H, Seinen W
Department of Veterinary Pharmacology, University of Utrecht, The Netherlands.
Environ Res. 1987 Dec;44(2):335-53. doi: 10.1016/s0013-9351(87)80242-6.
As a consequence of the rapid expansion of the uses and applications of the organotin compounds, the concern about their environmental and health effects is increasing. The main subject of this overview is the current understanding of the mammalian toxicity of the organotin compounds. Four different types of target organ toxicity, namely neurotoxicity, hepatoxicity, immunotoxicity, and cutaneous toxicity, are discussed in more detail. The effects of the organotin compounds on the mitochondrial and cellular level are summarized and discussed in relation to the mode of action of these compounds on the central nervous system, the liver and bile duct, the immune system, and the skin.
由于有机锡化合物的用途和应用迅速扩展，人们对其环境和健康影响的关注日益增加。本综述的主要主题是目前对有机锡化合物哺乳动物毒性的认识。更详细地讨论了四种不同类型的靶器官毒性，即神经毒性、肝毒性、免疫毒性和皮肤毒性。总结并讨论了有机锡化合物在线粒体和细胞水平上的影响，以及这些化合物对中枢神经系统、肝脏和胆管、免疫系统和皮肤的作用方式。
