Ahmann A J, Burman K D
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
Endocrinol Metab Clin North Am. 1987 Jun;16(2):287-326.
Abnormalities in cellular mechanisms of immunoregulation are important factors in the initiation and/or propagation of autoimmune thyroid disease and Graves' ophthalmopathy. The primary immunologic lesion, however, remains elusive despite increasingly sophisticated investigations in the areas of antigen presentation and subsequent T-cell responses. Emphasis on functional evaluations of relevant cell populations and advances in lymphokine analysis, interpretation of DR antigen expression, and T-cell cloning offer promise for our future understanding of this complex process.
免疫调节细胞机制的异常是自身免疫性甲状腺疾病和格雷夫斯眼病发生和/或发展的重要因素。然而，尽管在抗原呈递及随后的T细胞反应领域进行了越来越深入的研究，原发性免疫损伤仍然难以捉摸。对相关细胞群体进行功能评估以及在淋巴因子分析、DR抗原表达解读和T细胞克隆方面取得的进展，为我们未来理解这一复杂过程带来了希望。
