苯并吩噻嗪及其 Cr(III)-催化的交叉脱氢偶联反应。
Benzophenothiazine and Its Cr(III)-Catalyzed Cross Dehydrogenative Couplings.
机构信息
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
出版信息
Org Lett. 2020 Dec 4;22(23):9196-9198. doi: 10.1021/acs.orglett.0c03354. Epub 2020 Nov 16.
Abstract
In stark contrast to phenothiazines and their prevalence for cross-dehydrogenative amination reactions, benzophenothiazine has a pronounced preference for cross-dehydrogenative C-C bond-forming reactions. Moreover, the substrate is very versatile, leading to several new classes of C-C bond-forming reactions and many new oxidative coupling product architectures, including unprecedented indole fused paddlewheel-like structures.
摘要
与吩噻嗪类药物及其在交叉脱氢胺反应中的广泛应用形成鲜明对比的是，苯并吩噻嗪类药物对交叉脱氢 C-C 键形成反应表现出明显的偏好。此外，该底物具有非常广泛的适用性，导致了几种新的 C-C 键形成反应和许多新的氧化偶联产物结构，包括前所未有的吲哚稠合桨轮状结构。
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