School of Forestry, Henan Agricultural University, Zhengzhou, 450002, China.
Department of Chemistry, Payame Noor University, Tehran, Iran.
Top Curr Chem (Cham). 2020 Mar 31;378(2):37. doi: 10.1007/s41061-020-0300-1.
Aromatic amines belong to a highly important class of organic compounds which are found in various natural products, functional materials, and pharmaceutical agents. Their prevalence has sparked continuing interest in the development of highly efficient and environmentally benign synthetic strategies for the construction of these compounds. Cross-dehydrogenative coupling reactions between two unmodified C(X)-H bonds have recently emerged as a versatile and powerful strategy for the fabrication of new C(X)-C(X) bonds. In this context, several procedures have been reported for the synthesis of aromatic amines through the direct amination of aromatic C-H bonds with free amines. This review highlights recent advances and progress in this appealing research arena, with special emphasis on the mechanistic features of the reactions.
芳香胺属于一类非常重要的有机化合物，存在于各种天然产物、功能材料和药物制剂中。它们的广泛存在激发了人们持续的兴趣，促使人们开发高效、环境友好的合成策略，以构建这些化合物。两个未经修饰的 C(X)-H 键之间的交叉脱氢偶联反应最近已成为构建新的 C(X)-C(X)键的一种通用且强大的策略。在这种情况下，已经有几种方法被报道用于通过游离胺直接对芳环 C-H 键进行胺化反应来合成芳香胺。本文综述了该吸引人的研究领域中的最新进展和进展，特别强调了反应的机理特征。
