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评估完全合成健康数据中的身份披露风险:模型开发与验证

Evaluating Identity Disclosure Risk in Fully Synthetic Health Data: Model Development and Validation.

作者信息

El Emam Khaled, Mosquera Lucy, Bass Jason

机构信息

School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.

Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.

出版信息

J Med Internet Res. 2020 Nov 16;22(11):e23139. doi: 10.2196/23139.

DOI:10.2196/23139
PMID:33196453
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7704280/
Abstract

BACKGROUND

There has been growing interest in data synthesis for enabling the sharing of data for secondary analysis; however, there is a need for a comprehensive privacy risk model for fully synthetic data: If the generative models have been overfit, then it is possible to identify individuals from synthetic data and learn something new about them.

OBJECTIVE

The purpose of this study is to develop and apply a methodology for evaluating the identity disclosure risks of fully synthetic data.

METHODS

A full risk model is presented, which evaluates both identity disclosure and the ability of an adversary to learn something new if there is a match between a synthetic record and a real person. We term this "meaningful identity disclosure risk." The model is applied on samples from the Washington State Hospital discharge database (2007) and the Canadian COVID-19 cases database. Both of these datasets were synthesized using a sequential decision tree process commonly used to synthesize health and social science data.

RESULTS

The meaningful identity disclosure risk for both of these synthesized samples was below the commonly used 0.09 risk threshold (0.0198 and 0.0086, respectively), and 4 times and 5 times lower than the risk values for the original datasets, respectively.

CONCLUSIONS

We have presented a comprehensive identity disclosure risk model for fully synthetic data. The results for this synthesis method on 2 datasets demonstrate that synthesis can reduce meaningful identity disclosure risks considerably. The risk model can be applied in the future to evaluate the privacy of fully synthetic data.

摘要

背景

为便于共享数据进行二次分析,人们对数据合成的兴趣日益浓厚;然而,对于完全合成数据,需要一个全面的隐私风险模型:如果生成模型过度拟合,那么就有可能从合成数据中识别出个体并了解有关他们的新信息。

目的

本研究的目的是开发并应用一种方法来评估完全合成数据的身份泄露风险。

方法

提出了一个完整的风险模型,该模型评估身份泄露以及如果合成记录与真实个体匹配,对手了解新信息的能力。我们将此称为“有意义的身份泄露风险”。该模型应用于华盛顿州医院出院数据库(2007年)和加拿大COVID-19病例数据库的样本。这两个数据集均使用常用于合成健康和社会科学数据的顺序决策树过程进行合成。

结果

这两个合成样本的有意义身份泄露风险均低于常用的0.09风险阈值(分别为0.0198和0.0086),分别比原始数据集的风险值低4倍和5倍。

结论

我们提出了一个针对完全合成数据的全面身份泄露风险模型。该合成方法在两个数据集上的结果表明,合成可以显著降低有意义的身份泄露风险。该风险模型未来可用于评估完全合成数据的隐私性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ce2/7704280/29ca05760b75/jmir_v22i11e23139_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ce2/7704280/a2914b4cf4d9/jmir_v22i11e23139_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ce2/7704280/29ca05760b75/jmir_v22i11e23139_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ce2/7704280/a2914b4cf4d9/jmir_v22i11e23139_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ce2/7704280/29ca05760b75/jmir_v22i11e23139_fig2.jpg

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2
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Front Big Data. 2020 May 28;3:16. doi: 10.3389/fdata.2020.00016. eCollection 2020.
3
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Proc Natl Acad Sci U S A. 2025 Mar 4;122(9):e2409182122. doi: 10.1073/pnas.2409182122. Epub 2025 Feb 26.
4
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Front Artif Intell. 2025 Feb 5;8:1533508. doi: 10.3389/frai.2025.1533508. eCollection 2025.
5
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NPJ Digit Med. 2025 Jan 23;8(1):49. doi: 10.1038/s41746-025-01431-6.
6
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7
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PLoS One. 2024 Jul 31;19(7):e0308063. doi: 10.1371/journal.pone.0308063. eCollection 2024.
10
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JMIR AI. 2024 Apr 22;3:e52615. doi: 10.2196/52615.
Lancet Digit Health. 2020 Sep;2(9):e444-e446. doi: 10.1016/S2589-7500(20)30161-8. Epub 2020 Jul 24.
4
Less than five is less than ideal: replacing the "less than 5 cell size" rule with a risk-based data disclosure protocol in a public health setting.少于五是不理想的:在公共卫生环境中,用基于风险的数据披露协议取代“小于 5 个细胞大小”的规则。
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5
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