Armstrong April W, Hekmatjah Joshua, Kircik Leon H
J Drugs Dermatol. 2020 Nov 1;19(11):s6-s13.
Oral tetracyclines are the most widely prescribed systemic antibiotic for acne. Synthesis of efficacy and safety of traditional and novel oral tetracyclines is highly informative to clinical practice. We conducted a systematic search of PubMed to identify large interventional and observational studies utilizing oral tetracyclines as an acne treatment. We identified 13 articles meeting inclusion for this review, which represented 226,019 pediatric and adult acne patients. Oral tetracyclines that were included in this systematic review were sarecycline (a novel narrow-spectrum tetracycline), doxycycline, minocycline, and tetracycline. Based on shared and divergent outcome measures, different oral tetracyclines were variably effective against facial acne. Sarecycline also demonstrated efficacy in truncal acne. Members of the oral tetracycline class also differed in their ability to minimize antibiotic resistance and gut dysbiosis. J Drugs Dermatol. 2020;19:11(Suppl):s4-11.
口服四环素类药物是治疗痤疮最常用的全身性抗生素。综合传统和新型口服四环素类药物的疗效与安全性，对临床实践具有重要指导意义。我们对PubMed进行了系统检索，以确定使用口服四环素类药物治疗痤疮的大型干预性和观察性研究。我们筛选出13篇符合本次综述纳入标准的文章，这些文章涵盖了226,019例儿童和成人痤疮患者。本次系统综述纳入的口服四环素类药物包括sarecycline（一种新型窄谱四环素）、强力霉素、米诺环素和四环素。基于共同和不同的疗效指标，不同的口服四环素类药物对面部痤疮的疗效各不相同。Sarecycline对躯干痤疮也有疗效。口服四环素类药物在最小化抗生素耐药性和肠道菌群失调方面的能力也有所不同。《药物皮肤病学杂志》。2020年；19:11（增刊）：s4 - 11。
