Kim Yoon-Seob, Kim Hei Sung
Department of Dermatology, Bucheon St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea,
Department of Dermatology, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
Dermatology. 2024;240(5-6):844-858. doi: 10.1159/000542006. Epub 2024 Oct 18.
Tetracyclines are a class of broad-spectrum antibiotics favored by dermatologists. Over the last decade, the clinical efficacy of tetracyclines has expanded into various dermatoses.
This review tries to encompass the possible indications of tetracycline in the field of dermatology and possible mechanisms of action. This comprehensive review encompasses all possible indications of tetracyclines besides acne vulgaris and rosacea: hidradenitis suppurativa, autoimmune bullous dermatoses, vitiligo, alopecia, prurigo pigmentosa, granulomatous dermatoses, Kaposi's sarcoma, cold urticaria, atopic dermatitis, scrub typhus, scarring, and miscellaneous dermatoses. We also focus on the recently approved sarecycline, a third-generation narrow-spectrum tetracycline, and its clinical efficacy and potential impact on the microbiome. Our review provides a better understanding of this extremely familiar drug class and encourages its use in a wider spectrum of dermatologic diseases and symptoms.
This study comprehensively reviewed the current literature on potential indications of tetracyclines in the field of dermatology.
四环素是一类皮肤科医生青睐的广谱抗生素。在过去十年中，四环素的临床疗效已扩展到各种皮肤病。
本综述试图涵盖四环素在皮肤科领域的可能适应证及可能的作用机制。这一全面综述涵盖了寻常痤疮和玫瑰痤疮之外四环素的所有可能适应证：化脓性汗腺炎、自身免疫性大疱性皮肤病、白癜风、脱发、色素性痒疹、肉芽肿性皮肤病、卡波西肉瘤、寒冷性荨麻疹、特应性皮炎、恙虫病、瘢痕形成以及其他各类皮肤病。我们还重点关注了最近获批的第三代窄谱四环素——司美环素，及其临床疗效和对微生物群的潜在影响。我们的综述有助于更好地理解这一极为常见的药物类别，并鼓励其在更广泛的皮肤科疾病和症状中应用。
本研究全面回顾了四环素在皮肤科领域潜在适应证的当前文献。
