Department of Biotechnology, Bhupat and Jyoti Mehta School of BioSciences, Indian Institute of Technology Madras, Chennai 600 036, Tamilnadu, India.
Nucleic Acids Res. 2021 Jan 8;49(D1):D420-D424. doi: 10.1093/nar/gkaa1035.
ProThermDB is an updated version of the thermodynamic database for proteins and mutants (ProTherm), which has ∼31 500 data on protein stability, an increase of 84% from the previous version. It contains several thermodynamic parameters such as melting temperature, free energy obtained with thermal and denaturant denaturation, enthalpy change and heat capacity change along with experimental methods and conditions, sequence, structure and literature information. Besides, the current version of the database includes about 120 000 thermodynamic data obtained for different organisms and cell lines, which are determined by recent high throughput proteomics techniques using whole-cell approaches. In addition, we provided a graphical interface for visualization of mutations at sequence and structure levels. ProThermDB is cross-linked with other relevant databases, PDB, UniProt, PubMed etc. It is freely available at https://web.iitm.ac.in/bioinfo2/prothermdb/index.html without any login requirements. It is implemented in Python, HTML and JavaScript, and supports the latest versions of major browsers, such as Firefox, Chrome and Safari.
ProThermDB 是蛋白质和突变体热力学数据库（ProTherm）的更新版本，其中包含约 31500 个蛋白质稳定性数据，比上一版本增加了 84%。它包含了一些热力学参数，如熔点、热变性和变性剂变性获得的自由能、焓变和热容变，以及实验方法和条件、序列、结构和文献信息。此外，当前版本的数据库还包括了约 120000 个不同生物体和细胞系的热力学数据，这些数据是使用全细胞方法的最新高通量蛋白质组学技术确定的。此外，我们还提供了一个用于可视化序列和结构水平突变的图形界面。ProThermDB 与其他相关数据库（如 PDB、UniProt、PubMed 等）进行了交叉链接。它可以在没有任何登录要求的情况下，在 https://web.iitm.ac.in/bioinfo2/prothermdb/index.html 上免费获取。它是用 Python、HTML 和 JavaScript 实现的，支持 Firefox、Chrome 和 Safari 等主流浏览器的最新版本。
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