SIFTS：更新后的结构整合功能、分类学和序列资源允许基于结构注释的蛋白质覆盖率增加 40 倍。
SIFTS: updated Structure Integration with Function, Taxonomy and Sequences resource allows 40-fold increase in coverage of structure-based annotations for proteins.
机构信息
Protein Data Bank in Europe, European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Protein Function Development, European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
出版信息
Nucleic Acids Res. 2019 Jan 8;47(D1):D482-D489. doi: 10.1093/nar/gky1114.
The Structure Integration with Function, Taxonomy and Sequences resource (SIFTS; http://pdbe.org/sifts/) was established in 2002 and continues to operate as a collaboration between the Protein Data Bank in Europe (PDBe; http://pdbe.org) and the UniProt Knowledgebase (UniProtKB; http://uniprot.org). The resource is instrumental in the transfer of annotations between protein structure and protein sequence resources through provision of up-to-date residue-level mappings between entries from the PDB and from UniProtKB. SIFTS also incorporates residue-level annotations from other biological resources, currently comprising the NCBI taxonomy database, IntEnz, GO, Pfam, InterPro, SCOP, CATH, PubMed, Ensembl, Homologene and automatic Pfam domain assignments based on HMM profiles. The recently released implementation of SIFTS includes support for multiple cross-references for proteins in the PDB, allowing mappings to UniProtKB isoforms and UniRef90 cluster members. This development makes structure data in the PDB readily available to over 1.8 million UniProtKB accessions.
结构整合与功能、分类学和序列资源（SIFTS；http://pdbe.org/sifts/）成立于 2002 年，目前仍由欧洲蛋白质数据库（PDBe；http://pdbe.org）和 UniProt 知识库（UniProtKB；http://uniprot.org）共同合作运营。该资源通过提供 PDB 和 UniProtKB 条目之间最新的残基级别的映射，在蛋白质结构和蛋白质序列资源之间的注释转移方面发挥了重要作用。SIFTS 还整合了来自其他生物资源的残基级注释，目前包括 NCBI 分类数据库、IntEnz、GO、Pfam、InterPro、SCOP、CATH、PubMed、Ensembl、Homologene 和基于 HMM 图谱的自动 Pfam 结构域分配。最近发布的 SIFTS 实现支持 PDB 中蛋白质的多个交叉引用，允许映射到 UniProtKB 同工型和 UniRef90 聚类成员。这一发展使得 PDB 中的结构数据可用于超过 180 万的 UniProtKB 访问号。
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