Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Halal Research Center of IRI, FDA, Tehran, Iran.
Complement Ther Med. 2021 Jan;56:102608. doi: 10.1016/j.ctim.2020.102608. Epub 2020 Nov 4.
We identified and quantified the results of randomized clinical trials by examining the effect of barberry supplementation on blood pressure.
We conducted a comprehensive search in the medical bibliographic database up to May 2020 on randomized clinical trials investigating the effect of barberry supplementation on adult blood pressure. Intensive literature searches and data extraction according to a prefixed scheme was performed independently by two investigators.
Through 5 randomized clinical trial studies, 350 subjects with 175 cases for the intervention group and 175 cases for control group were included in our study. The intervention period ranged from 4 to 12 weeks. In general, barberry supplementation did not have a significant effect on systolic blood pressure (WMD: -4.15 mmHg; 95 % CI: -10.3, 1.99, P = 0.185) and diastolic blood pressure (WMD: -1.22 mmHg; 95 % CI: -6.26, 3.82, P = 0.635). Our study was heterogeneous and subgroup analysis did not eliminate heterogeneity.
Totally, based on this study, we cannot conclude that barberry supplementation has beneficial effects on blood pressure. Also, all included studies had limitations such as different in geographical situations, Dietary of participants, health conditions, and pharmacological forms of berberis. Therefore, further study in this area is recommended.
通过研究贯叶连翘补充剂对血压的影响，确定并量化随机临床试验的结果。
我们对截至 2020 年 5 月的医学文献数据库进行了全面检索，以调查贯叶连翘补充剂对成人血压影响的随机临床试验。两名研究者根据预设方案独立进行了深入的文献检索和数据提取。
通过 5 项随机临床试验研究，我们共纳入了 350 名受试者，其中干预组 175 例，对照组 175 例。干预时间从 4 周到 12 周不等。总体而言，贯叶连翘补充剂对收缩压（WMD：-4.15mmHg；95%CI：-10.3，1.99，P=0.185）和舒张压（WMD：-1.22mmHg；95%CI：-6.26，3.82，P=0.635）没有显著影响。我们的研究存在异质性，且亚组分析未能消除异质性。
基于本研究，我们不能得出贯叶连翘补充剂对血压有益的结论。此外，所有纳入的研究都存在局限性，如参与者的地理位置、饮食、健康状况和小檗碱的药理学形式不同。因此，建议在该领域开展进一步的研究。
