小檗（Berberis vulgaris L.）是一种安全的管理脂质参数的方法：随机对照试验的系统评价和荟萃分析。
Barberry (Berberis vulgaris L.) is a safe approach for management of lipid parameters: A systematic review and meta-analysis of randomized controlled trials.
机构信息
Halal Research Center of IRI, FDA, Tehran, Iran; Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Complement Ther Med. 2019 Apr;43:117-124. doi: 10.1016/j.ctim.2019.01.017. Epub 2019 Jan 24.
OBJECTIVE
We performed a meta-analysis to evaluate the efficacy of barberry supplementation on plasma lipid concentration in adult population.
METHODS
The search included PubMed, Scopus, ISI Web of Science, Cochrane library, and Google Scholar (up to October 2018) to identify randomized controlled trials (RCTs) investigating the effects of barberry supplementation on serum lipid parameters. Mean Difference (MD) was pooled using a random-effects model.
RESULTS
Meta-analysis on 5 RCTs with 339 participants indicated that barberry supplementation significantly decreased the levels of total cholesterol (MD: -23.58 mg/dl, 95% CI: -31.00 to -16.16, P ≤ 0.001), triglyceride (MD: -29.16 mg/dl, 95% CI: -42.91 to -15.41, P ≤ 0.001), and low-density lipoprotein cholesterol (MD: -13.75 mg/dl, 95% CI: -19.31 to -8.20, P ≤ 0.001) whereas changes in high-density lipoprotein cholesterol (MD: 3.40 mg/dl, 95% CI: -0.06-6.87, P = 0.054) was not statistically significant.
CONCLUSION
This systematic review and meta-analysis suggested the efficacy of barberry supplementation on lipid parameters. However, further large-scale studies are needed to confirm these results.
目的
我们进行了一项荟萃分析，以评估小檗碱补充剂对成年人群血浆脂质浓度的疗效。
方法
检索了 PubMed、Scopus、ISI Web of Science、Cochrane 图书馆和 Google Scholar（截至 2018 年 10 月），以确定关于小檗碱补充剂对血清脂质参数影响的随机对照试验（RCT）。使用随机效应模型汇总均数差（MD）。
结果
对 5 项 RCT（339 名参与者）进行的荟萃分析表明，小檗碱补充剂可显著降低总胆固醇水平（MD：-23.58mg/dl，95%CI：-31.00 至-16.16，P≤0.001）、甘油三酯（MD：-29.16mg/dl，95%CI：-42.91 至-15.41，P≤0.001）和低密度脂蛋白胆固醇（MD：-13.75mg/dl，95%CI：-19.31 至-8.20，P≤0.001），而高密度脂蛋白胆固醇（MD：3.40mg/dl，95%CI：0.06-6.87，P=0.054）的变化无统计学意义。
结论
本系统评价和荟萃分析表明，小檗碱补充剂对血脂参数有效。然而，需要进一步的大规模研究来证实这些结果。
Zotero 插件