• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

DLG1-AS1/miR-497/YAP1 轴调控甲状腺乳头状癌细胞的进展。

The DLG1-AS1/miR-497/YAP1 axis regulates papillary thyroid cancer progression.

机构信息

Department of Nuclear Medicine, The First Hospital of Jilin University, Changchun 130021, China.

Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun 130021, China.

出版信息

Aging (Albany NY). 2020 Nov 16;12(22):23326-23336. doi: 10.18632/aging.104121.

DOI:10.18632/aging.104121
PMID:33197895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7746333/
Abstract

The long non-coding RNA (lncRNA), DLG1-AS1, is upregulated in papillary thyroid cancer (PTC) tissues and cell lines. Here, we found that increased expression of DLG1-AS1 caused lymph node metastasis and advanced tumor-node-metastasis (TNM) stage. DLG1-AS1 knockdown inhibited proliferation, invasion, and migration of PTC cells, and impaired tumorigenesis in mouse xenografts. DLG1-AS1 functions as a competing endogenous RNA (ceRNA) for miR-497. Further investigation revealed that DLG1-AS1 regulated yes-associated protein 1 (YAP1; a known target of miR-497) by competitively binding to miR-497. Moreover, inhibition of miR-497 abrogated the inhibitory effects of DLG1-AS1 depletion on PTC cells. These findings demonstrate that the DLG1-AS1-miR-497-YAP1 axis promotes the growth and metastasis of PTC by forming a ceRNA network.

摘要

长链非编码 RNA（lncRNA）DLG1-AS1 在甲状腺乳头状癌（PTC）组织和细胞系中上调。在这里，我们发现 DLG1-AS1 的表达增加导致了淋巴结转移和更晚期的肿瘤-淋巴结-转移（TNM）分期。DLG1-AS1 的敲低抑制了 PTC 细胞的增殖、侵袭和迁移，并损害了小鼠异种移植中的肿瘤发生。DLG1-AS1 作为 miR-497 的竞争性内源性 RNA（ceRNA）发挥作用。进一步的研究表明，DLG1-AS1 通过竞争性结合 miR-497 来调节 yes 相关蛋白 1（YAP1；miR-497 的已知靶标）。此外，抑制 miR-497 消除了 DLG1-AS1 耗竭对 PTC 细胞的抑制作用。这些发现表明，DLG1-AS1-miR-497-YAP1 轴通过形成 ceRNA 网络促进 PTC 的生长和转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8af/7746333/d01d4e6270af/aging-12-104121-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8af/7746333/0121030fd3a0/aging-12-104121-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8af/7746333/54a82ad1bc48/aging-12-104121-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8af/7746333/a098598f37f8/aging-12-104121-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8af/7746333/87f46dabedb9/aging-12-104121-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8af/7746333/4af0ed5b6548/aging-12-104121-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8af/7746333/d01d4e6270af/aging-12-104121-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8af/7746333/0121030fd3a0/aging-12-104121-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8af/7746333/54a82ad1bc48/aging-12-104121-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8af/7746333/a098598f37f8/aging-12-104121-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8af/7746333/87f46dabedb9/aging-12-104121-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8af/7746333/4af0ed5b6548/aging-12-104121-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8af/7746333/d01d4e6270af/aging-12-104121-g006.jpg

相似文献

1
The DLG1-AS1/miR-497/YAP1 axis regulates papillary thyroid cancer progression.DLG1-AS1/miR-497/YAP1 轴调控甲状腺乳头状癌细胞的进展。
Aging (Albany NY). 2020 Nov 16;12(22):23326-23336. doi: 10.18632/aging.104121.
2
LncRNA SNHG15 acts as a ceRNA to regulate YAP1-Hippo signaling pathway by sponging miR-200a-3p in papillary thyroid carcinoma.长链非编码 RNA SNHG15 通过海绵吸附 miR-200a-3p 调控 YAP1-Hippo 信号通路在甲状腺乳头状癌中的作用。
Cell Death Dis. 2018 Sep 20;9(10):947. doi: 10.1038/s41419-018-0975-1.
3
Silencing long non-coding RNAs nicotinamide nucleotide transhydrogenase antisense RNA 1 inhibited papillary thyroid cancer cell proliferation, migration and invasion and promoted apoptosis via targeting miR-199a-5p.沉默长链非编码 RNA 烟酰胺核苷酸转氢酶反义 RNA 1 通过靶向 miR-199a-5p 抑制甲状腺乳头状癌细胞增殖、迁移和侵袭并促进细胞凋亡。
Endocr J. 2021 May 28;68(5):583-597. doi: 10.1507/endocrj.EJ20-0353. Epub 2021 Mar 20.
4
LncRNA TNRC6C-AS1 regulates UNC5B in thyroid cancer to influence cell proliferation, migration, and invasion as a competing endogenous RNA of miR-129-5p.长链非编码 RNA TNRC6C-AS1 通过作为 miR-129-5p 的竞争性内源 RNA 调控甲状腺癌细胞中的 UNC5B 影响细胞增殖、迁移和侵袭。
J Cell Biochem. 2018 Nov;119(10):8304-8316. doi: 10.1002/jcb.26868. Epub 2018 Jun 12.
5
STAT3-induced upregulation of lncRNA ABHD11-AS1 promotes tumour progression in papillary thyroid carcinoma by regulating miR-1301-3p/STAT3 axis and PI3K/AKT signalling pathway.STAT3 诱导的长链非编码 RNA ABHD11-AS1 的上调通过调节 miR-1301-3p/STAT3 轴和 PI3K/AKT 信号通路促进甲状腺乳头状癌的肿瘤进展。
Cell Prolif. 2019 Mar;52(2):e12569. doi: 10.1111/cpr.12569. Epub 2019 Jan 18.
6
LncRNA GAS8-AS1 suppresses papillary thyroid carcinoma cell growth through the miR-135b-5p/CCND2 axis.长链非编码 RNA GAS8-AS1 通过 miR-135b-5p/CCND2 轴抑制甲状腺乳头状癌细胞生长。
Biosci Rep. 2019 Jan 11;39(1). doi: 10.1042/BSR20181440. Print 2019 Jan 31.
7
Long non-coding RNA TTN-AS1 facilitates tumorigenesis of papillary thyroid cancer through modulating the miR-153-3p/ZNRF2 axis.长链非编码 RNA TTN-AS1 通过调节 miR-153-3p/ZNRF2 轴促进甲状腺乳头状癌的发生。
J Gene Med. 2019 May;21(5):e3083. doi: 10.1002/jgm.3083. Epub 2019 Mar 25.
8
A novel lncRNA n384546 promotes thyroid papillary cancer progression and metastasis by acting as a competing endogenous RNA of miR-145-5p to regulate AKT3.一种新的长链非编码 RNA n384546 通过作为 miR-145-5p 的竞争性内源性 RNA 来调节 AKT3，促进甲状腺乳头状癌的进展和转移。
Cell Death Dis. 2019 Jun 3;10(6):433. doi: 10.1038/s41419-019-1637-7.
9
Altered expression of DLG1-AS1 distinguished papillary thyroid carcinoma from benign thyroid nodules.DLG1-AS1 的异常表达可将甲状腺乳头状癌与良性甲状腺结节区分开来。
BMC Endocr Disord. 2019 Nov 12;19(1):122. doi: 10.1186/s12902-019-0440-x.
10
Long non-coding RNA LINC00152 promotes cell growth and invasion of papillary thyroid carcinoma by regulating the miR-497/BDNF axis.长链非编码 RNA LINC00152 通过调节 miR-497/BDNF 轴促进甲状腺乳头状癌的细胞生长和侵袭。
J Cell Physiol. 2019 Feb;234(2):1336-1345. doi: 10.1002/jcp.26928. Epub 2018 Aug 26.

引用本文的文献

1
Identification and validation of a prognostic anoikis-related gene signature in papillary thyroid carcinoma by integrated analysis of single-cell and bulk RNA-sequencing.通过单细胞和批量 RNA 测序的综合分析鉴定和验证甲状腺乳头状癌中与失巢凋亡相关的预后基因特征。
Medicine (Baltimore). 2024 May 10;103(19):e38144. doi: 10.1097/MD.0000000000038144.
2
E-cadherin loss drives diffuse-type gastric tumorigenesis via EZH2-mediated reprogramming.E-钙黏蛋白缺失通过 EZH2 介导的重编程驱动弥漫型胃肿瘤发生。
J Exp Med. 2024 Apr 1;221(4). doi: 10.1084/jem.20230561. Epub 2024 Feb 27.
3
MicroRNA-181b-5p Facilitates Thyroid Cancer Growth via Targeting Programmed Cell Death 4.

本文引用的文献

1
Long noncoding RNA SNHG22 increases ZEB1 expression via competitive binding with microRNA-429 to promote the malignant development of papillary thyroid cancer.长链非编码 RNA SNHG22 通过与 microRNA-429 竞争结合增加 ZEB1 表达，促进甲状腺乳头状癌的恶性发展。
Cell Cycle. 2020 May;19(10):1186-1199. doi: 10.1080/15384101.2020.1749466. Epub 2020 Apr 19.
2
Characterization of lncRNA LINC00520 and functional polymorphisms associated with breast cancer susceptibility in Chinese Han population.LINC00520 的特征分析及与中国汉族人群乳腺癌易感性相关的功能性多态性。
Cancer Med. 2020 Mar;9(6):2252-2268. doi: 10.1002/cam4.2893. Epub 2020 Jan 29.
3
MicroRNA-181b-5p 通过靶向细胞程序性死亡 4 促进甲状腺癌生长。
Mol Biotechnol. 2024 May;66(5):1154-1164. doi: 10.1007/s12033-023-01013-5. Epub 2024 Jan 22.
4
A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma.LINC00475介导的甲状腺乳头状癌中的ceRNA网络
Open Med (Wars). 2021 Dec 6;17(1):22-33. doi: 10.1515/med-2021-0389. eCollection 2022.
5
Identification of Hub lncRNAs Along With lncRNA-miRNA-mRNA Network for Effective Diagnosis and Prognosis of Papillary Thyroid Cancer.用于甲状腺乳头状癌有效诊断和预后的枢纽lncRNAs以及lncRNA-miRNA-mRNA网络的鉴定
Front Pharmacol. 2021 Oct 13;12:748867. doi: 10.3389/fphar.2021.748867. eCollection 2021.
Long non-coding RNA ASMTL-AS1 inhibits tumor growth and glycolysis by regulating the miR-93-3p/miR-660/FOXO1 axis in papillary thyroid carcinoma.
长链非编码 RNA ASMTL-AS1 通过调控 miR-93-3p/miR-660/FOXO1 轴抑制甲状腺乳头状癌肿瘤生长和糖酵解。
Life Sci. 2020 Mar 1;244:117298. doi: 10.1016/j.lfs.2020.117298. Epub 2020 Jan 14.
4
Altered expression of DLG1-AS1 distinguished papillary thyroid carcinoma from benign thyroid nodules.DLG1-AS1 的异常表达可将甲状腺乳头状癌与良性甲状腺结节区分开来。
BMC Endocr Disord. 2019 Nov 12;19(1):122. doi: 10.1186/s12902-019-0440-x.
5
Reciprocal Crosstalk Between YAP1/Hippo Pathway and the p53 Family Proteins: Mechanisms and Outcomes in Cancer.YAP1/河马通路与p53家族蛋白之间的相互串扰：癌症中的机制与结果
Front Cell Dev Biol. 2019 Aug 9;7:159. doi: 10.3389/fcell.2019.00159. eCollection 2019.
6
Long noncoding RNAs in thyroid cancer.长链非编码 RNA 在甲状腺癌中的作用。
Curr Opin Endocrinol Diabetes Obes. 2019 Oct;26(5):275-281. doi: 10.1097/MED.0000000000000497.
7
Up-regulated lncRNA XIST contributes to progression of cervical cancer via regulating miR-140-5p and .上调的长链非编码RNA XIST通过调控miR-140-5p等促进宫颈癌进展。
Cancer Cell Int. 2019 Feb 28;19:45. doi: 10.1186/s12935-019-0744-y. eCollection 2019.
8
Long Non-Coding RNAs in Thyroid Cancer: Implications for Pathogenesis, Diagnosis, and Therapy.长链非编码 RNA 在甲状腺癌中的作用：对发病机制、诊断和治疗的启示。
Oncol Res Treat. 2019;42(3):136-142. doi: 10.1159/000495151. Epub 2019 Feb 23.
9
LncRNA SNHG15 acts as a ceRNA to regulate YAP1-Hippo signaling pathway by sponging miR-200a-3p in papillary thyroid carcinoma.长链非编码 RNA SNHG15 通过海绵吸附 miR-200a-3p 调控 YAP1-Hippo 信号通路在甲状腺乳头状癌中的作用。
Cell Death Dis. 2018 Sep 20;9(10):947. doi: 10.1038/s41419-018-0975-1.
10
lncRNA DLG1-AS1 Promotes Cell Proliferation by Competitively Binding with miR-107 and Up-Regulating ZHX1 Expression in Cervical Cancer.长链非编码RNA DLG1-AS1通过与miR-107竞争性结合并上调ZHX1表达促进宫颈癌细胞增殖。
Cell Physiol Biochem. 2018;49(5):1792-1803. doi: 10.1159/000493625. Epub 2018 Sep 19.