Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Expert Opin Pharmacother. 2021 Apr;22(6):695-703. doi: 10.1080/14656566.2020.1849141. Epub 2020 Nov 16.
: Estimates of the prevalence of comorbid depression vary, ranging from 9 and 62%. Deterioration of mental health may emerge as a result of psoriasis; however, it is theorized that depression alone may independently predispose patients to new-onset psoriasis.: The aim of this brief review is to explore the impact of depression on psoriasis treatment.: The two studies that directly assess the role of depression in psoriasis treatment outcomes are important, as unaddressed depression can undermine the success of a given treatment. This may reflect the notion that depressed individuals are less likely to be adherent. Thus, it may be valuable for clinicians to not only screen for depression, but to ensure that it is adequately treated. Our knowledge of treatment preferences in psoriasis patients with comorbid depression is limited. Expanding our understanding of preferences may allow providers to better align their recommendations to ultimately increase adherence. Additionally, given that many psoriasis treatments have an impact on depression, it may be beneficial for clinicians to evaluate patients for psychiatric risk factors to optimize the treatment regimen.
: 共病性抑郁的患病率估计值差异很大，范围从 9%到 62%。心理健康状况的恶化可能是由于银屑病引起的；然而，据推测，抑郁本身可能会使患者独立易患新发银屑病。: 本简要综述旨在探讨抑郁对银屑病治疗的影响。: 直接评估抑郁在银屑病治疗结果中的作用的两项研究非常重要，因为未解决的抑郁会破坏特定治疗的成功。这可能反映了一个观点，即抑郁的个体不太可能坚持治疗。因此，临床医生不仅要筛查抑郁，还要确保对其进行充分治疗，这可能很有价值。我们对伴有共病性抑郁的银屑病患者的治疗偏好知之甚少。扩大我们对偏好的理解可能使提供者能够更好地调整他们的建议，最终增加依从性。此外，鉴于许多银屑病治疗方法会影响抑郁，评估患者的精神风险因素可能对优化治疗方案有益。
