Tan Minjia, Luo Yan, Hu Jingjin, Hu Kun, Li Xingyu, Yang Jing, Chen Junchen, Zhu Wu, Kuang Yehong
The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, People's Republic of China.
Clin Cosmet Investig Dermatol. 2023 Feb 13;16:397-405. doi: 10.2147/CCID.S401934. eCollection 2023.
Psoriasis patients often suffers from anxiety and depression. Inflammation, anxiety, and depression have been associated with each other, but the relationship has not been examined in subjects with psoriasis. The primary objective was to investigate the relationship between the C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) and depression among patients with psoriasis.
In this case-control, cross-sectional study, 239 individuals with psoriasis and 142 with healthy controls (HCs) were recruited. Psychological as well as clinical, and laboratory data were collected.
50.2% of subjects with psoriasis reported depressive symptoms, compared with 26.8% of HCs. 39.7% and 17.6% observed anxiety symptoms in psoriasis patients and HCs. The odds of anxiety (AOR= 3.123; 95% CI = 1.851-5.269) and depression (AOR= 2.698; 95% CI = 1.690-4.306) were higher in psoriasis patients relative to HCs. Furthermore, the elevated CRP (AOR =2.139; 95% CI = 1.249-3.663) and ESR (AOR =1.827; 95% CI = 1.078-3.096) were the risk factors of depression in patients with psoriasis. The threshold for distinguish psoriasis patients in depression was 3.24 (area under the curve [AUC], 0.605; sensitivity, 0.57; specificity, 0.64) for CRP and 26.5 (AUC, 0.632; sensitivity, 0.52; specificity, 0.73) for ESR.
A substantial prevalence of anxiety and depression symptoms was observed in Chinese psoriasis subjects, and the odds were much higher in psoriasis patients relative to HCs. The elevated CRP and ESR level was significantly associated with depression in psoriasis patients. Besides, the discrimination capability of CPR and ESR on depression further indicates the extra value of inflammatory biomarkers in the management of psoriasis patients.
银屑病患者常伴有焦虑和抑郁。炎症、焦虑和抑郁之间相互关联，但这种关系在银屑病患者中尚未得到研究。主要目的是探讨银屑病患者中C反应蛋白（CRP）、红细胞沉降率（ESR）与抑郁之间的关系。
在这项病例对照横断面研究中，招募了239例银屑病患者和142例健康对照者（HCs）。收集了心理、临床和实验室数据。
50.2%的银屑病患者报告有抑郁症状，而健康对照者中这一比例为26.8%。39.7%的银屑病患者和17.6%的健康对照者存在焦虑症状。与健康对照者相比，银屑病患者出现焦虑（优势比[AOR]=3.123；95%置信区间[CI]=1.851 - 5.269）和抑郁（AOR=2.698；95% CI = 1.690 - 4.306）的几率更高。此外，CRP升高（AOR =2.139；95% CI = 1.249 - 3.663）和ESR升高（AOR =1.827；95% CI = 1.078 - 3.096）是银屑病患者抑郁的危险因素。区分银屑病抑郁患者的CRP阈值为3.24（曲线下面积[AUC]，0.605；敏感性，0.57；特异性，0.64），ESR阈值为26.5（AUC，0.632；敏感性，0.52；特异性，0.73）。
在中国银屑病患者中观察到焦虑和抑郁症状的患病率较高，且银屑病患者出现这些症状的几率相对于健康对照者要高得多。CRP和ESR水平升高与银屑病患者的抑郁显著相关。此外，CRP和ESR对抑郁的鉴别能力进一步表明炎症生物标志物在银屑病患者管理中的额外价值。
