Ophthalmic Plastic Surgery Service, LV Prasad Eye Institute, Hyderabad, India.
Ophthalmic Plastic and Facial Aesthetic, Orbit and Ocular Oncology, LV Prasad Eye Institute, Vijaywada, India.
Orbit. 2022 Apr;41(2):170-177. doi: 10.1080/01676830.2020.1846761. Epub 2020 Nov 17.
To compare the retinal vascularity, peripapillary vascularity, nerve fiber layer thickness and ganglion cell layer thickness between active, inactive thyroid eye disease (TED) and healthy eyes.
Retrospective comparative cross-sectional cohort study. Patients with TED, active and inactive on the VISA score, and healthy eyes were included. All patients underwent optical coherence tomography angiography with detailed demographic and clinical data capture. Using automated software, retinal and peripapillary vascularity index, nerve fiber layer thickness, and ganglion cell layer thickness were calculated and were compared between the groups.
Twenty-four eyes with active TED, 102 eyes with inactive TED and 52 healthy eyes were included. Independent sample t test was used to compare parametric data and Mann-Whitney test to compare non-parametric data. The age and gender were comparable across groups. The peripapillary vascularity index (26.82 ± 4.13 versus 34.92 ± 5.08, = .002) and the macular vascularity index (20.32 ± 2.5 versus 31.21 ± 3.89, < .0001) were reduced in active TED eyes versus inactive eyes. Macular vascularity index was comparable in the inactive versus the healthy eyes. The RNFL thickness was increased in the active TED eyes versus the inactive eyes (45.11 ± 18.3 versus 35.55 ± 7, = .03) and active versus healthy eyes (45.11 ± 18.3 versus 36.28 ± 7.89, = .03). Ganglion cell layer thickness between all three groups was comparable.
Decrease in peripapillary and macular vascular density and increase in RNFL thickness are seen in active TED compared to inactive TED and healthy eyes. In disease inactivity, these parameters are comparable to healthy eyes.
比较活动期、非活动期甲状腺相关眼病（TED）与正常眼的视网膜血管密度、视盘周围血管密度、神经纤维层厚度和节细胞层厚度。
回顾性对比性横断面队列研究。纳入 TED 患者，根据 VISA 评分分为活动期和非活动期，同时纳入正常眼。所有患者均行光学相干断层血管造影术，并详细记录人口统计学和临床数据。使用自动软件计算视网膜和视盘周围血管密度指数、神经纤维层厚度和节细胞层厚度，并比较各组之间的差异。
纳入 24 只活动期 TED 眼、102 只非活动期 TED 眼和 52 只正常眼。采用独立样本 t 检验比较参数数据，采用 Mann-Whitney 检验比较非参数数据。三组的年龄和性别无差异。与非活动期 TED 眼相比，活动期 TED 眼的视盘周围血管密度指数（26.82±4.13 与 34.92±5.08， =.002）和黄斑血管密度指数（20.32±2.5 与 31.21±3.89， <.0001）均降低。非活动期 TED 眼的黄斑血管密度指数与正常眼无差异。与非活动期 TED 眼相比，活动期 TED 眼的神经纤维层厚度增加（45.11±18.3 与 35.55±7， =.03），与正常眼相比也增加（45.11±18.3 与 36.28±7.89， =.03）。三组间节细胞层厚度无差异。
与非活动期 TED 眼和正常眼相比，活动期 TED 眼的视盘周围和黄斑血管密度降低，神经纤维层厚度增加。在疾病非活动期，这些参数与正常眼相似。
