Department of Physiology, Seoul National University College of Medicine, Republic of Korea.
Department of Physiology and Ion Channel Disease Research Center, Dongguk University College of Medicine, Seoul, Republic of Korea.
Biochem Biophys Res Commun. 2021 Jan 1;534:590-596. doi: 10.1016/j.bbrc.2020.11.035. Epub 2020 Nov 14.
Calcium homeostasis modulator 1 (calhm1) proteins form an outwardly rectifying nonselective ion channel having exceedingly slow kinetics and low sensitivity to voltage that is shifted by lowering extracellular Ca ([Ca]). Here we found that physiological temperature dramatically facilitates the voltage-dependent activation of the calhm1 current (I); increased amplitude (Q, 7-15) and fastened speed of activation. Also, the leftward shift of the half-activation voltage (V) was similary observed in the normal and lower [Ca]. Since calhm1 is highly expressed in the brain and taste cells, the thermosensitivity should be considered in their electrophysiology.
钙稳态调节剂 1（calhm1）蛋白形成一种具有超慢动力学和对电压极低敏感性的外向整流非选择性离子通道，其可通过降低细胞外 Ca([Ca])来移位。在这里，我们发现生理温度可极大促进 calhm1 电流（I）的电压依赖性激活；增加幅度（Q，7-15）并加快激活速度。此外，在正常和较低的[Ca]下也观察到半激活电压（V）的向左移位。由于 calhm1 在大脑和味觉细胞中高度表达，因此在其电生理学中应考虑热敏感性。
